Topical analgesics for acute and chronic pain in adults - an overview of Cochrane Reviews.

The Cochrane Database of Systematic Reviews
Sheena DerryR Andrew Moore

Abstract

Topical analgesic drugs are used for a variety of painful conditions. Some are acute, typically strains or sprains, tendinopathy, or muscle aches. Others are chronic, typically osteoarthritis of hand or knee, or neuropathic pain. To provide an overview of the analgesic efficacy and associated adverse events of topical analgesics (primarily nonsteroidal anti-inflammatory drugs (NSAIDs), salicylate rubefacients, capsaicin, and lidocaine) applied to intact skin for the treatment of acute and chronic pain in adults. We identified systematic reviews in acute and chronic pain published to February 2017 in the Cochrane Database of Systematic Reviews (the Cochrane Library). The primary outcome was at least 50% pain relief (participant-reported) at an appropriate duration. We extracted the number needed to treat for one additional beneficial outcome (NNT) for efficacy outcomes for each topical analgesic or formulation, and the number needed to treat for one additional harmful outcome (NNH) for adverse events. We also extracted information on withdrawals due to lack of efficacy or adverse events, systemic and local adverse events, and serious adverse events. We required information from at least 200 participants, in at least two studies....Continue Reading

References

Feb 18, 1995·BMJ : British Medical Journal·R J Cook, D L Sackett
Feb 3, 1999·Lancet·C J Hawkey
Jan 21, 2000·Journal of Pain and Symptom Management·J E EdwardsS L Collins
Mar 24, 2000·Journal of Clinical Epidemiology·A Thornton, P Lee
Aug 11, 2001·The New England Journal of Medicine·G A FitzGerald, C Patrono
Aug 4, 2005·Journal of Child Health Care : for Professionals Working with Children in the Hospital and Community·Ewa IdvallIngrid Runeson
Feb 17, 2007·BMC Medical Research Methodology·Beverley J SheaLex M Bouter
Apr 20, 2007·The Cochrane Database of Systematic Reviews·W KhaliqN Puri
Feb 8, 2008·Journal of Computer-aided Molecular Design·Robert D Clark, Daniel J Webster-Clark
Jul 22, 2008·Rheumatic Diseases Clinics of North America·R Andrew MooreHenry J McQuay
Jul 10, 2009·The Cochrane Database of Systematic Reviews·Miranda CumpstonRachelle Buchbinder
Sep 15, 2009·Pain·R A MooreUNKNOWN ACTINPAIN writing group of the IASP Special Interest Group (SIG) on Systematic Reviews in Pain Relief
Jan 22, 2010·The Cochrane Database of Systematic Reviews·Xuejun CuiYong-Jun Wang
Apr 21, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·N AttalT Nurmikko
Jul 16, 2010·Pain·R Andrew MooreUNKNOWN Cochrane Pain, Palliative and Supportive Care Systematic Review Group Editors
Jul 20, 2010·BMJ : British Medical Journal·Eveline NüeschPeter Jüni
Sep 28, 2010·Current Biology : CB·Marjolein P M KammersPatrick Haggard
Feb 18, 2011·The Cochrane Database of Systematic Reviews·Melainie CameronSigrun Chrubasik
Aug 2, 2011·Journal of Clinical Epidemiology·Gordon H GuyattUNKNOWN GRADE Working Group
May 23, 2012·Journal of Clinical Epidemiology·Gordon H GuyattHolger J Schünemann
Sep 14, 2012·The Cochrane Database of Systematic Reviews·Sheena Derry, R Andrew Moore
Dec 12, 2012·International Journal of Cardiology·Zaina AlBalawiJørn Wetterslev
Mar 8, 2013·Pain Practice : the Official Journal of World Institute of Pain·R AndrewCeri J Phillips
Apr 26, 2013·BMJ : British Medical Journal·Agnes DechartresPhilippe Ravaud
May 7, 2013·BMJ : British Medical Journal·Andrew MooreEija Kalso
Jun 4, 2013·The Cochrane Database of Systematic Reviews·Porjai PattanittumRachelle Buchbinder
Jun 4, 2013·The Cochrane Database of Systematic Reviews·Melainie Cameron, Sigrun Chrubasik
Jan 10, 2014·BMJ : British Medical Journal·Liliane ZorzelaSunita Vohra
Jul 23, 2014·Maturitas·Helen GaskellR Andrew Moore
Jul 25, 2014·The Cochrane Database of Systematic Reviews·Sheena DerryJane Quinlan
Aug 15, 2014·JAMA : the Journal of the American Medical Association·Agnes DechartresPhilippe Ravaud
Jan 1, 2010·The Cochrane Database of Systematic Reviews·R Andrew MooreHenry J McQuay
Nov 27, 2014·The Cochrane Database of Systematic Reviews·Sheena DerryR Andrew Moore
Dec 24, 2014·The Cochrane Database of Systematic Reviews·Hanna OlteanJoel J Gagnier

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Citations

Aug 30, 2018·Postgraduate Medicine·E C Rodriguez-Merchan
Sep 4, 2018·The Journal of Small Animal Practice·V Re BravoE Vettorato
Sep 29, 2019·Der Schmerz·Miriam KaislerChristine H Meyer-Frießem
Feb 23, 2019·Turkish Journal of Emergency Medicine·David H Cisewski, Sergey M Motov
Aug 21, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Dmitry M DavydovBruce Naliboff
Jan 16, 2020·Scandinavian Journal of Pain·Mona StedenfeldtVidar Halsteinli
Jun 22, 2018·British Journal of Sports Medicine·Benjamin E SmithPip Logan
Dec 6, 2019·Postgraduate Medical Journal·Michael F BathJ E F Fitzgerald
May 7, 2020·Haemophilia : the Official Journal of the World Federation of Hemophilia·Melanie BladenDavid Stephensen
Sep 24, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Amanda C de C Williams
Jul 1, 2019·Scandinavian Journal of Pain·Jens-Christian Trojel HviidHenrik Bjarke Vaegter
Apr 17, 2019·Experimental and Therapeutic Medicine·Ahmad A AltarifiMohammad I Alsalem
Jan 17, 2020·Current Medical Research and Opinion·Philip J Wiffen, Jun Xia
Aug 19, 2020·Age and Ageing·Mireia Felez-NobregaAi Koyanagi
Sep 7, 2020·Scandinavian Journal of Pain·Leontien M van RavesteynArianne P Verhagen
Feb 6, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Alberto Marcos Heredia-RizoPascal Madeleine
Aug 6, 2020·Korean journal of anesthesiology·Eunjoo ChoiJihun Jo
Jun 7, 2018·Pain and Therapy·Fabiola AtzeniPiercarlo Sarzi-Puttini
Aug 23, 2020·International Journal of Environmental Research and Public Health·Corrado GiuaUmberto M Musazzi
Sep 9, 2020·Assistive Technology : the Official Journal of RESNA·Danielle Brasil-Barros-da-Silva, Emerson Fachin-Martins
Aug 18, 2018·Der Internist·M M Wertli, J Steurer
Jul 11, 2020·Physiotherapy Research International : the Journal for Researchers and Clinicians in Physical Therapy·Laura G W CoxRoss A Iles
May 6, 2020·Medicine and Science in Sports and Exercise·Henrik Bjarke VaegterJonas Bloch Thorlund
Jun 15, 2020·Neuroscience and Biobehavioral Reviews·Nick ToddDavid Borsook
Feb 4, 2021·Current Pain and Headache Reports·Jillian MaloneyNatalie Strand
Jan 10, 2021·Animals : an Open Access Journal From MDPI·Paul C MillsMichael McGowan
Nov 22, 2020·Neurology International·Amber EdinoffIvan Urits

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