PMID: 9423913Jan 10, 1998Paper

Topical anesthesia with pH-adjusted versus standard lidocaine 4% for clear corneal cataract surgery

Journal of Cataract and Refractive Surgery
Martin ZehetmayerR Menapace

Abstract

To evaluate and compare the efficacy of a sodium-bicarbonate-adjusted preparation of lidocaine 4% (pH = 7.2) and standard lidocaine (pH = 5.2) for topical anesthesia in clear corneal cataract surgery. Department of Ophthalmology, University of Vienna, Austria. In a prospective, randomized, double-blind clinical trial, clear corneal cataract surgery was performed under topical anesthesia in 44 eyes of 34 patients. In 22 eyes, pH-adjusted lidocaine 4% was administered; in the other 22, standard lidocaine 4%. Aqueous and serum concentrations of lidocaine were measured by high-performance liquid chromatography and ultraviolet detection. Subjective pain was assessed using a visual analog scale of no pain (0%) to worst imaginable pain (100%). On the first postoperative day, visual acuity, intraocular pressure, and corneal staining with fluorescein were examined. In the pH-adjusted lidocaine group, significantly higher lidocaine concentrations were found in the aqueous humor (15.06 microg/mL +/- 8.2 [SD] versus 4.75 +/- 3.5 microg/mL; P < .0001). In all samples (n = 8), serum lidocaine concentrations were below a minimum detectable level of 0.02 microg/mL. Subjective pain ratings were similar in the pH-adjusted and standard lidocaine ...Continue Reading

References

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Citations

Sep 2, 1999·Journal of Clinical Anesthesia·B KleinmanR Belusko
Jan 26, 2000·Journal of Cataract and Refractive Surgery·D M Harman
May 20, 1999·Journal of Cataract and Refractive Surgery·R BellucciG Magnolfi
May 20, 1999·Journal of Cataract and Refractive Surgery·C WirbelauerH Laqua
Apr 17, 2002·Journal of Cataract and Refractive Surgery·Gabriele Fuchsjäger-MayrlKlaus Turnheim
Oct 3, 2003·Journal of Cataract and Refractive Surgery·Ruby LagnadoRaghavan Sampath
Oct 6, 2000·Journal of Cataract and Refractive Surgery·P EggelingP W Rieck
Oct 21, 2004·The Journal of the American Dental Association·Scott S MeitDorian Williams
May 23, 2015·The Cochrane Database of Systematic Reviews·M Soledad CepedaRoman Schumann
Oct 26, 2005·Journal of Cataract and Refractive Surgery·Soon-Phaik Chee, Kristine Bacsal
Sep 9, 2017·Veterinary Anaesthesia and Analgesia·Patricia C DuarteRafael R Faleiros

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