PMID: 9161648May 1, 1997Paper

Topical antimicrobial prophylaxis in minor wounds

The Annals of Pharmacotherapy
J H LangfordS I Benrimoj

Abstract

To evaluate the ability of a novel topical antimicrobial gel containing cetrimide, bacitracin, and polymyxin B sulfate to prevent infections of minor wounds. A clinical trial compared the test preparation with placebo and a povidone iodine antiseptic cream. Five primary schools in Sydney, Australia, participated in the study over a 6-week spring/summer school term. Children aged 5-12 years with parental consent were eligible for study participation. Accidental injuries occurring at school were treated in a standardized manner by nurses at each site. Wounds were evaluated by the medical practitioner after 3 days of topical treatment. The clinical outcome was classified as resolution or suspected infection. If a clinical infection was suspected, the injury was swabbed for microbiologic evaluation. Growth of a dominant microorganism was classified as a microbiologic infection. Of the 177 injuries treated, there were nine clinical infections. A comparison of these showed a significant difference among treatment groups (p < 0.05). This difference was associated with the test preparation and placebo; the test preparation reduced the incidence of clinical infection from 12.5% to 1.6% (p < 0.05; 95% CI, 0.011 to 0.207). A comparison of...Continue Reading

References

Nov 11, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·T R BeamC M Kunin
Jul 1, 1990·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D N GilbertC M Kunin
Sep 1, 1990·The Journal of Antimicrobial Chemotherapy·R C SpencerE H Brown
Oct 1, 1989·The Pediatric Infectious Disease Journal·E L Ford-JonesR Gold
Nov 1, 1986·The Journal of Hospital Infection·M J Abussaud, M M Meqdem
Aug 1, 1985·Journal of the American Academy of Dermatology·J S MaddoxH C Dillon
Oct 1, 1984·Burns, Including Thermal Injury·B H Bowser-WallaceF T Caldwell
Sep 1, 1984·The Journal of Antimicrobial Chemotherapy·R Norrby
Mar 1, 1984·The Journal of Antimicrobial Chemotherapy·P Davey
Feb 1, 1980·The Surgical Clinics of North America·P J Cruse, R Foord
Oct 1, 1994·Controlled Clinical Trials·M Borenstein

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Citations

Jul 27, 2005·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Michael J Messingham, Christopher J Arpey
Jan 22, 2017·Advances in Therapy·George Han, Roger Ceilley
Oct 7, 2009·Expert Review of Anti-infective Therapy·Ronald PangilinanGlenn Tillotson
Jan 17, 2017·Journal of Athletic Training·Joel W BeamMario Ciocca
Aug 17, 2004·Infectious Disease Clinics of North America·Peter A Lio, Elaine T Kaye
Jun 1, 2000·Infectious Disease Clinics of North America·E T Kaye
Nov 17, 2009·Infectious Disease Clinics of North America·Peter A Lio, Elaine T Kaye
Jan 21, 2011·Journal of the American Academy of Dermatology·Zoe D DraelosNathan S Trookman
Jun 18, 2011·The Medical Clinics of North America·Peter A Lio, Elaine T Kaye

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