Topical application of epidermal growth factor accelerates wound healing by myofibroblast proliferation and collagen synthesis in rat.

Journal of Veterinary Science
Young-Bae KwonJang-Hern Lee

Abstract

Recombinant human epidermal growth factor (rhEGF) stimulates the proliferation and migration of epithelial cells in human cell culture systems and animal models of partial-thickness skin wounds. This study investigated the effect of a topical rhEGF ointment on the rate of wound healing and skin re-epithelialization in a rat full thickness wound model, and verified whether or not the rhEGF treatment affected both myofibroblast proliferation and collagen synthesis in the dermis. When rhEGF (10 microgram/g ointment) was applied topically twice a day for 14 days, there was significantly enhanced wound closure from the 5th to the 12th day compared with the control (ointment base treatment) group. A histological examination at the postoperative 7th day revealed that the rhEGF treatment increased the number of proliferating nuclear antigen immunoreactive cells in the epidermis layer. In addition, the immunoreactive area of alpha-smooth muscle actin and the expression of prolyl 4-hydroxylase were significantly higher than those of the control group. Overall, a topical treatment of rhEGF ointment promotes wound healing by increasing the rate of epidermal proliferation and accelerating the level of wound contraction related to myofibrobl...Continue Reading

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Citations

Dec 24, 2010·The Journal of Veterinary Medical Science·Ayman AtibaYuji Uzuka
Jan 1, 2010·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Zouhir DjerrouA Boukeloua
Sep 2, 2008·Medical Hypotheses·Dawon KangJungbin Park
Jun 5, 2015·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·In Gyu HwangHyo-Jin Kim
Jan 21, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Mohan L Gope, Rajalakshmi Gope
Dec 1, 2014·Medicina clínica·Jordi Esquirol Caussa, Elisabeth Herrero Vila
Sep 17, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Naqi Lian, Taiping Li
Mar 31, 2012·Journal of the American Podiatric Medical Association·Guojuan LaoYujun Zhou
Dec 1, 2015·Archives of Plastic Surgery·Yang Woo KimYoung Woo Cheon
Sep 11, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Takuro MiyazakiAkira Miyazaki
Sep 4, 2015·Biomolecules & Therapeutics·Dongsun ParkYun-Bae Kim
May 17, 2017·Ultrastructural Pathology·Abeer A MahmoudEman M Askar
Nov 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Arun Prabhu RameshbabuSantanu Dhara
Aug 14, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Joseph HardwickeRuth Duncan
Jun 28, 2020·Burns : Journal of the International Society for Burn Injuries·Mohammad Hossein Farjah, Mohammad Reza Farahpour
Apr 3, 2021·Journal of Tissue Engineering·Jihyun KimJin Woo Lee
Jul 10, 2018·Advanced Drug Delivery Reviews·Patricia RousselleGuila Dayan

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