Topical application of herbal formula for the treatment of ligature-induced periodontitis

Journal of Periodontal & Implant Science
Mi Hye KimWoong Mo Yang

Abstract

The aim of this study was to investigate the therapeutic effects of a herbal formula, PerioH-035, containing Angelica sinensis, steamed Rehmannia glutinosa, Angelica dahurica, Cimicifuga heracleifolia, and Zanthoxylum piperitum on the periodontal breakdown in a well-established ligature-induced periodontitis model in rats. Sprague-Dawley rats were randomly assigned to 1 of 4 groups: NL (non-ligatured), L (ligatured), P1 (ligatured and treated with 1 mg/mL PerioH-035), P100 (ligatured and treated with 100 mg/mL PerioH-035). Periodontitis was induced by placing a ligature around the mandibular first molars. PerioH-035 was topically applied to both sides of the first molar for 2 weeks. The right side of the mandibles was retrieved for micro-computed tomography (CT) and methylene blue staining to analyze alveolar bone loss. The left side of the mandibles was histologically analyzed by TRAP and H&E staining. The MMP-9 mRNA level in gingival tissue was investigated by RT-PCR. Alveolar bone resorption was significantly reduced in the PerioH-035-treated groups. The number of dense multi-nucleated cells found to be TRAP-positive by staining in the ligatured rats was markedly decreased by PerioH-035 application. In addition, periodontal ...Continue Reading

References

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Apr 23, 2014·Journal of Ethnopharmacology·You Yeon ChoiWoong Mo Yang

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Citations

Aug 23, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Graciela Rocha DonaldFabio Boylan

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Methods Mentioned

BETA
PCR

Software Mentioned

Image J
Leica Application Suite ( LAS )
Quantity One

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