Topical Application of High-Dose Mesna Prevents Adhesion Formation: An Experimental Animal Study

The Journal of Surgical Research
Mustafa BerkesogluMusa M Dirlik

Abstract

Adhesion formation is a common complication of abdominal surgeries. Mesna is a drug with fibrinolytic properties which has been used in surgical field to facilitate tissue dissection. The aim of this experimental animal study was to investigate the effect of mesna on prevention of intra-abdominal adhesion in rats. Twenty-eight Wistar albino rats were used in the study. To create abdominal adhesion, cecum was abraded in all rats. No additional surgical procedure was performed other than adhesion in group 1 (only adhesion). In the other groups, rats were treated topically by administering 0.9% saline (group 2), 40 mg/kg mesna (group 3), and 400 mg/kg mesna (group 4). All rats were sacrificed on postoperative 21st day. Histopathological and macroscopic evaluations of adhesion formation were performed. Quantity of adhesion scores (P = 0.022), severity of adhesion scores (P = 0.041), total adhesion scores (P = 0.023), and histopathological adhesion grading scores (P < 0.001) were reduced by 400 mg/kg mesna. This is the first study for mesna on prevention of abdominal adhesion formation in rats. We concluded that dose-dependent reduction of adhesion was achieved by mesna. With future studies, topical administration of mesna during op...Continue Reading

Citations

Sep 2, 2020·Acta Biomaterialia·Jingyi TangShengfu Chen
Aug 19, 2021·Journal of Voice : Official Journal of the Voice Foundation·Okan ÖvünçGülben Erdem Huq

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Miranda VerschraagenWim J F van der Vijgh
DICP : the Annals of Pharmacotherapy
M H Gilleece, J M Davies
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
M P GorenW P Brade
© 2021 Meta ULC. All rights reserved