Topical application of lipopolysaccharide into gingival sulcus promotes periodontal destruction in rats immunized with lipopolysaccharide

Journal of Periodontal Research
Y YoshinagaY Hara

Abstract

The causes of periodontitis are bacteria and the host immune system, but the role of the immune system in the onset and progression of periodontal disease is still unclear. Our previous report showed that the formation of an immune complex in the gingival sulcus induces periodontal destruction. This study was carried out to investigate how the immune system, particularly immunization, is involved in periodontal destruction. Animals immunized intraperitoneally with lipopolysaccharide (LPS) were used as the immunized group. The nonimmunized group received only phosphate-buffered saline. LPS was applied daily onto the palatal gingival sulcus in both groups 1 d after the booster injection. Serum levels of anti-LPS IgG were determined. Loss of attachment and the level of alveolar bone were histopathologically and histometrically investigated. RANKL-bearing cells and the expression of C1qB were immunohistologically evaluated. The serum levels of anti-LPS IgG were elevated in the early experimental period in the immunized group. There were significant increases in loss of attachment, level of alveolar bone and the number of RANKL-bearing cells in the immunized group. C1qB was observed in the junctional epithelium and adjacent connecti...Continue Reading

References

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Jul 6, 2010·Biochemical Pharmacology·George Hajishengallis

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Citations

Jan 26, 2016·Clinical Oral Implants Research·Yuzo TakamoriTakashi Sawase
Dec 2, 2017·Periodontology 2000·Nikolaos DonosXanthippi Dereka
Mar 11, 2020·Journal of Periodontal Research·Yoichi AritaRyuji Sakagami
Jan 26, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Azar Hosseini, Hossein Hosseinzadeh

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