Topical application of PPARα (but not β/δ or γ) suppresses atopic dermatitis in NC/Nga mice

Allergy
T ChibaM Furue

Abstract

Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors, which regulate not only adipogenesis and proliferation/differentiation but also the immune response of cells. Because topical application of the activators of some PPAR isoforms improved clinical symptoms in patients with atopic dermatitis (AD), we investigated the role of PPAR activators using a murine AD model in NC/Nga mice; to the best of our knowledge, this has not been previously reported. Activators of three PPAR isoforms (α, β/δ, γ) were topically applied on inflamed skin in a murine AD model that was developed by repeated topical application of mite antigen in NC/Nga mice. The efficacy of each topical PPAR activator was evaluated immunologically and serologically. Topical application of the PPARα activator, but not of the activators of PPARβ/δ or PPARγ, improved clinical dermatitis, reduced inflammatory cell infiltration in the dermis, and alleviated the elevation of serum IgE levels. In addition, PPARα expression was downregulated in the epidermis in our murine AD model, as is seen in patients with AD. Topical application of PPARα activator could be a potent therapeutic agent for patients with AD and could take the place of topical steroid trea...Continue Reading

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Citations

Dec 10, 2013·Biochimica Et Biophysica Acta·Matthias SchmuthSandrine Dubrac
Oct 30, 2013·The Journal of Investigative Dermatology·Arianna MastrofrancescoMauro Picardo
Jan 15, 2014·Allergy·A Wollenberg, K Feichtner
Feb 1, 2019·Journal of Medicinal Chemistry·Julius PollingerDaniel Merk
Aug 28, 2021·International Journal of Molecular Sciences·Raymond L KongerMatthew J Turner

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Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.