Topical application of substance P promotes wound healing in streptozotocin-induced diabetic rats

Cytokine
Vinay KantSurender K Tandan

Abstract

Substance P (SP) is known to stimulate angiogenesis, fibroblasts proliferation and expressions of cytokines and growth factors involved in wound healing. However, SP level reduces in dermis in diabetics and, hence, it was hypothesized that exogenously applied SP could be helpful in improving wound healing in diabetic rats. Excision skin wound was created on the back of diabetic rats and rats were divided into three groups i.e. (i) saline-, (ii) gel- and (iii) SP-treated. Normal saline, pluronic gel and SP (10(-6)M) in gel were topically applied once daily for 19days. SP treatment significantly increased the wound closure, levels of interleukin-10, and expressions of vascular endothelial growth factor, transforming growth factor-beta1, heme oxygenase-1 and endothelial nitric oxide synthase, whereas it significantly decreased the expression of tumor necrosis factor-alpha, interleukin-1beta and matrix metalloproteinases-9 in the granulation/healing tissue. The inflammatory cells were present for long time in normal saline-treated group. Histological evaluation revealed better extracellular matrix formation with marked fibroblast proliferation and collagen deposition in SP-treated group. Early epithelial layer formation, increased ...Continue Reading

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Citations

Dec 19, 2015·Cellular and Molecular Life Sciences : CMLS·Ian A DarbyAlexis Desmoulière
Jan 11, 2016·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jihyun UmKi-Sook Park
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May 12, 2020·Frontiers in Immunology·Dong-Jin KimSang-Ho Lee
Sep 12, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Da Jung KimJungsun Lee
Sep 13, 2019·International Journal of Molecular Sciences·Da Jung KimJungsun Lee
Feb 20, 2021·Reproductive Biology and Endocrinology : RB&E·Xiaofang XuSun-Wei Guo
Apr 16, 2021·The International Journal of Lower Extremity Wounds·Vinay KantDinesh Kumar
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Jul 20, 2021·Immunopharmacology and Immunotoxicology·Vinay KantVinay G Joshi
Feb 21, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Satish PatelDeependra Singh

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