Topical application of the immunosuppressant tacrolimus accelerates carcinogenesis in mouse skin

The British Journal of Dermatology
Y NiwaH Sumi

Abstract

Tacrolimus, produced by the fungus Streptomyces tsukabaensis, is a potent macrolide immunosuppressant widely used in liver and kidney transplantation. Topical tacrolimus has recently been found to be an effective treatment for atopic dermatitis (AD). Because of the well-known association between T-cell immunosuppression and an increased risk of carcinogenesis, we investigated the effect of topical tacrolimus on skin carcinogenesis in 117 mice. Approximately 8 cm2 of the shaved dorsal skin of 7-week-old female CD-1 mice was treated with 7,12-dimethylbenz[alpha]anthracene (DMBA) dissolved in acetone, which is in general use as a tumour initiator, or acetone alone, on day 1 of the experiment, followed by promoting treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) with or without tacrolimus, or acetone with or without tacrolimus, for 20 weeks. The mice were divided into six treatment groups: (1) DMBA followed by acetone; (2) DMBA followed by TPA; (3) DMBA followed by acetone + tacrolimus; (4) DMBA followed by TPA + tacrolimus; (5) acetone followed by acetone + tacrolimus; and (6) acetone followed by acetone (control). The induction of skin tumours was significantly greater in the TPA-treated groups than in the absence of TP...Continue Reading

References

Jun 1, 1988·Current Problems in Surgery·M A NalesnikT E Starzl
Mar 1, 1983·Archives of Dermatology·B Sina, J W Burnett
Dec 1, 1995·The British Journal of Dermatology·J C NoelP Galand
Mar 1, 1997·International Journal of Dermatology·M A SiddiquiA M al-Mofadhi
Nov 5, 1998·The Journal of Allergy and Clinical Immunology·T Bieber
Mar 8, 1999·Molecular Cell Biology Research Communications : MCBRC·T KohyamaK Yamamoto
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
May 29, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·C C Otley, M R Pittelkow
Jun 9, 2000·Clinical and Experimental Dermatology·I S Nasr
Jun 30, 2000·Japanese Journal of Cancer Research : Gann·T MorikawaS Fukushima
Jan 1, 1959·Psychological Bulletin·T A RYAN

❮ Previous
Next ❯

Citations

Sep 6, 2005·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·E EnderleinB Homey
Nov 16, 2005·Clinical Obstetrics and Gynecology·Tanja Gizela Bohl
Jan 20, 2005·The British Journal of Dermatology·T Langeland, V Engh
Apr 27, 2007·Dermatology : International Journal for Clinical and Investigative Dermatology·David J MargolisWarren Bilker
Apr 9, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Eric Wooltorton
Aug 8, 2009·American Journal of Clinical Dermatology·Paul D Yesudian
May 18, 2011·World Journal of Gastrointestinal Pharmacology and Therapeutics·Ian Craig Lawrance
Nov 26, 2010·Expert Opinion on Emerging Drugs·Sharon EladInger von Bültzingslöwen
Jul 28, 2010·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Yun WuHong-mei Zhou
Jul 9, 2010·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Ulf MattssonMats Jontell
Oct 20, 2009·Journal of the American Academy of Dermatology·Khalid A Al JohaniStefano Fedele
Nov 22, 2005·The Journal of Investigative Dermatology·Daniel B YaroshDavid A Brown
Jan 31, 2008·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Lida RadfarLakshmanan Suresh
Sep 8, 2007·The British Journal of Oral & Maxillofacial Surgery·Crispian Scully, Marco Carrozzo
Dec 21, 2005·The Veterinary Clinics of North America. Small Animal Practice·Rosanna Marsella
Nov 5, 2005·Journal of the European Academy of Dermatology and Venereology : JEADV·J RingP van de Kerkhof
May 14, 2005·Skinmed·Ronni WolfLawrence Charles Parish
Sep 3, 2008·Alimentary Pharmacology & Therapeutics·I C Lawrance, T-S Copeland
Apr 17, 2008·The Australasian Journal of Dermatology·Emma Starritt, Stephen Lee
Sep 15, 2007·The British Journal of Dermatology·M H A Rustin
Jan 17, 2007·The British Journal of Dermatology·J CallenB U Wintroub
Apr 28, 2011·Veterinary Ophthalmology·Jennifer DreyfusRichard R Dubielzig
Aug 29, 2012·Clinical and Experimental Dermatology·J RautavaT Soukka
Jul 9, 2009·Phytotherapy Research : PTR·Farzaneh Agha-HosseiniAida Karagah
Dec 3, 2014·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Anna Yuan, Sook-Bin Woo
Oct 14, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·S RiberoL Borradori
Sep 8, 2010·American Journal of Obstetrics and Gynecology·Verena von FelbertMosaad Megahed
Jun 14, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·S Ribero, L Borradori
Aug 3, 2014·BMJ Case Reports·Jigar M Purani, Hiral J Purani
Feb 4, 2010·Acta Cirúrgica Brasileira·Cristiano Machado InácioCarmen Australia Paredes Marcondes
Mar 14, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ian C LawranceSusan Connor
Nov 29, 2016·Indian Journal of Sexually Transmitted Diseases and AIDS·Surabhi Dayal, Priyadarshini Sahu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.