Topical Application of Wogonin Provides a Novel Treatment of Knee Osteoarthritis

Frontiers in Physiology
Jacob F SmithDavid L Kooyman

Abstract

Osteoarthritis (OA) is a degenerative joint disease characterized by inflammatory degradation of articular cartilage and subchondral bone. Wogonin, a compound extracted from the plant Scutellaria baicalensis (colloquially known as skullcap), has previously been shown to have direct anti-inflammatory and antioxidative properties. We examined the pain-reducing, anti-inflammatory, and chondroprotective effects of wogonin when applied as a topical cream. We validated the efficacy of delivering wogonin transdermally in a cream using pig ear skin in a Franz diffusion system. Using a surgical mouse model, we examined the severity and progression of OA with and without the topical application of wogonin. Using a running wheel to track activity, we found that mice with wogonin treatment were statistically more active than mice receiving vehicle treatment. OA progression was analyzed using modified Mankin and OARSI scoring and direct quantification of cyst-like lesions at the chondro-osseus junction; in each instance we observed a statistically significant attenuation of OA severity among mice treated with wogonin compared to the vehicle treatment. Immunohistochemistry revealed a significant decrease in protein expression of transforming...Continue Reading

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Citations

Nov 10, 2020·Molecular Biology Reports·Do Luong HuynhCuong Thach Nguyen
Feb 20, 2021·Journal of Experimental Pharmacology·Gundula Schulze-Tanzil
May 1, 2021·Animals : an Open Access Journal From MDPI·Baishuang YinXuezhao Sun

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