PMID: 1315212Jun 1, 1992

Topical application of WR-2721 to prevent radiation-induced proctosigmoiditis. A phase I/II trial

Cancer
G S MontanaE F Gaydica

Abstract

Patients undergoing x-ray therapy to the pelvis have intestinal symptoms proportional to the volume treated and the dose delivered. WR-2721, S-2 (3-aminopropylaminoethyl) phosphorothioic acid, is an organic thiophosphate compound that selectively protects normal tissues against radiation effects. A Phase I/II study was done to test the ability of topical application of WR-2721 to protect the mucosa of the rectosigmoid from radiation damage. Thirty-one patients were enrolled in this study, of which, seven were control subjects. Twenty-four patients received WR-2721 daily, in enema form, 45 minutes before treatment. The patients were assigned by groups of three to receive increasing doses of WR-2721 beginning with 100 mg/enema to 450 mg/enema. Rectal mucosal biopsies were obtained within the treated field before, during, and at the end of therapy. The degree of damage to the rectal mucosa was scored on the basis of a 0 to 4 scale (with 0, least damage to 4, most damage) as determined by the percentage of damaged mucosal crypt glands. The patients' symptoms were recorded once a week during the entire course of therapy. The biopsy scores of the control group were slightly higher than those of the treatment groups; however, this dif...Continue Reading

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·M M KligermanZ Zhang
Jun 1, 1988·International Journal of Radiation Oncology, Biology, Physics·M M KligermanP Rubin
May 1, 1989·International Journal of Radiation Oncology, Biology, Physics·F A Stewart
Aug 1, 1988·International Journal of Radiation Oncology, Biology, Physics·E L TravisI Basic
Jan 1, 1989·International Journal of Radiation Oncology, Biology, Physics·G S Montana, W C Fowler
May 1, 1986·International Journal of Radiation Oncology, Biology, Physics·E L TravisI Kiss
Sep 1, 1986·Gastroenterology·H G FranceC M Mansbach
Sep 1, 1987·International Journal of Radiation Oncology, Biology, Physics·E L TravisS J Helbing
Feb 1, 1986·International Journal of Radiation Oncology, Biology, Physics·H ItoL Milas
Sep 1, 1984·International Journal of Radiation Oncology, Biology, Physics·M M KligermanR L Goodman
Mar 1, 1982·International Journal of Radiation Oncology, Biology, Physics·A L BlumbergM M Kligerman

Citations

Jan 1, 1995·Digestive Diseases and Sciences·J L HerreraA Dubois
May 14, 2005·International Journal of Radiation Oncology, Biology, Physics·Vassilis KoulouliasL Vlahos
Jun 19, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·P C O'Brien
Jul 20, 2002·International Journal of Radiation Oncology, Biology, Physics·Edgar Ben-JosefIrving Kaplan
Dec 10, 1999·Journal of the American College of Surgeons·B E WaddellN J Petrelli
Jan 5, 2008·Nature Clinical Practice. Gastroenterology & Hepatology·Ole Haagen NielsenJørgen Rask-Madsen
Aug 8, 2001·The British Journal of Surgery·D HayneP B Boulos
May 2, 2002·Anti-cancer Drugs·M I Koukourakis
Aug 21, 2009·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Akiko ChinoRikiya Fujita
Mar 8, 2006·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·F AbbasakoorP B Boulos
Dec 26, 2008·World Journal of Gastroenterology : WJG·Jannis Kountouras, Christos Zavos
Feb 15, 2012·International Journal of Radiation Oncology, Biology, Physics·Cheryl M SorefWilliam E Fahl
Jul 18, 2008·Supportive Cancer Therapy·Martin Borg
Nov 1, 1993·American Journal of Surgery·J P DelaneyI Felemovicius
Feb 1, 1997·The Surgical Clinics of North America·T J Saclarides
Jun 19, 2012·Radiation Research·Daniel D PeeblesWilliam E Fahl
Jun 12, 2010·Journal of Experimental & Clinical Cancer Research : CR·Konstantinos H KatsanosEpameinondas V Tsianos
May 9, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vassilis Kouloulias, J Kouvaris
Jul 3, 2007·The Oncologist·J KouvarisLampros J Vlahos
Mar 31, 2006·Journal of Radiation Research·Mutsumi Matsuu-MatsuyamaIchiro Sekine

Related Concepts

Administration, Topical
Drug Evaluation
Ethyol
Structure of Intestinal Gland
Rectocolitis, Ulcerative
Radiation Syndrome

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.