Topical application with conjugated linoleic acid ameliorates 2, 4-dinitrofluorobenzene-induced atopic dermatitis-like lesions in BALB/c mice.

Experimental Dermatology
Liu TangHong Ding

Abstract

Atopic dermatitis (AD) is a multifactorial chronic inflammatory skin disease characterized by skin barrier dysfunction, eczematous lesions, pruritus, and abnormal immune responses. In this study, we assessed the therapeutic effect of topical applied conjugated linoleic acid (CLA) on a murine AD model that was developed by repetitive applications of 2, 4-dinitrofluorobenzene (DNFB). 2% or 5% CLA could markedly ameliorate AD-like skin lesions, scratching behaviour and skin inflammation as evidenced by the reduced inflammatory blood cells, IgE and Th2-related cytokine levels, and the infiltration of mast cells and inflammatory cells to the dermal tissues. Moreover, topical application with CLA modulated skin barrier repair including maintaining a balanced skin pH and increasing skin hydration, partially mediated by upregulating skin barrier-related protein, filaggrin (FLG). In addition, topical CLA significantly dose-dependently inhibited pro-inflammatory cytokines including interleukin (IL)-6, IL-1β, tumour necrosis factor (TNF)-α and pro-inflammatory enzyme expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in inflamed mice skin. Its anti-inflammatory effect was associated with the inhibition of D...Continue Reading

References

Jan 1, 1996·Annual Review of Immunology·A S Baldwin
Jun 1, 1997·The Journal of Nutrition·P W Parodi
Nov 14, 2000·Molecular Medicine Today·S S Makarov
Dec 31, 2005·Journal of the American Academy of Dermatology·Ulrich R HenggeMichael J Cork
May 3, 2006·The Journal of Nutritional Biochemistry·Arunabh BhattacharyaGabriel Fernandes
Oct 28, 2006·The Journal of Investigative Dermatology·Akane TanakaHiroshi Matsuda
Nov 17, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R K KanwarG W Krissansen
Aug 7, 2009·Current Allergy and Asthma Reports·Peter M Elias, Matthias Schmuth
Sep 2, 2009·The Journal of Allergy and Clinical Immunology·Michael D HowellDonald Y M Leung
May 29, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Josep Bassaganya-Riera, Raquel Hontecillas
Sep 30, 2010·Yonsei Medical Journal·Sang Eun LeeSeung Hun Lee
Mar 25, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·X SunG W Krissansen
Jun 21, 2011·Immunological Reviews·Mark Boguniewicz, Donald Y M Leung
Aug 5, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·V MlitzE Tschachler
Feb 26, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Peter D ArkwrightUNKNOWN Atopic Dermatitis Working Group of the Allergic Skin Diseases Committee of the AAAAI
Jun 11, 2014·Critical Reviews in Food Science and Nutrition·Tao Wang, Hong Gu Lee
May 1, 2015·Annals of Nutrition & Metabolism·Sophie Nutten
May 20, 2015·European Journal of Pharmacology·Monica ViladomiuJosep Bassaganya-Riera
Sep 24, 2015·The Journal of Investigative Dermatology·Hyosun JangAkane Tanaka
Jan 15, 2016·The Journal of Investigative Dermatology·Hyosun JangAkane Tanaka
Nov 26, 2016·Immunology and Allergy Clinics of North America·Makiko Kido-NakaharaTakeshi Nakahara
Jan 7, 2017·Allergology International : Official Journal of the Japanese Society of Allergology·Masutaka FurueTakafumi Kadono
Jun 6, 2017·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Lin LinLedong Sun
Jun 7, 2017·The Journal of Allergy and Clinical Immunology·Tali CzarnowickiEmma Guttman-Yassky
Oct 25, 2017·Advances in Experimental Medicine and Biology·W David BootheMichelle B Tarbox
May 30, 2019·International Journal of Molecular Sciences·Wen-Chung HuangShu-Ju Wu
Sep 8, 2019·Acta Médica Portuguesa·Tiago TorresPaulo Filipe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved