PMID: 350263May 1, 1978

Topical atenolol versus pilocarpine: a double-blind study of the effect on ocular tension

The British Journal of Ophthalmology
K WettrellM Pandolfi


Topical atenolol (a beta1-adrenoceptive antagonist), pilocarpine, and placebo were tested in a randomised double-blind crossover trial of 8 patients with ocular hypertenion. Atenolol (2% 3 times a day) caused a fall in intraocular pressure (IOP) comparable to that achieved by topical application of pilocarpine (2% 3 times a day). The decrease in IOP by each compound was demonstrable on the second day of application and was significantly (P is less than 0.05) reduced on the seventh and 14th days of treatment. The combination of 2% pilocarpine and 2% atenolol administered 15 minutes apart (3 times a day) lowered the IOP significantly from the second day of treatment, and this reduction persisted throughout the trial period of 14 days. This combined of treatment, treatment lowered the IOP more than either substance alone. However, this further decrease was statistically significant only on the 14th day of treatment (atenolol versus atenolol + pilocarpine, P is less than 0.05). No change of the episcleral venous pressure was observed after 14 days' treatment with either atenolol or pilocarpine alone, or combined.


Nov 1, 1976·The British Journal of Ophthalmology·M J MacdonaldC I Phillips
Dec 11, 1976·British Medical Journal·C I PhillipsP M Cullen
Jun 1, 1975·The British Journal of Ophthalmology·M J ElliotC I Phillips
Apr 22, 1977·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·G K KrieglsteinW Leydhecker
Apr 1, 1977·Archives of Ophthalmology·T J Zimmerman, H E Kaufman
May 1, 1977·The British Journal of Ophthalmology·K Wettrell, M Pandolfi
May 1, 1977·The British Journal of Ophthalmology·M J MacdonaldC I Phillips
May 1, 1977·The British Journal of Ophthalmology·C I PhillipsP M Cullen
Jun 1, 1975·The British Journal of Ophthalmology·I Bonomi, P Steindler
Mar 1, 1973·The British Journal of Ophthalmology·J Vale, C I Phillips
Oct 1, 1972·The British Journal of Ophthalmology·J ValeC I Phillips


Jan 1, 1985·Journal of Ocular Pharmacology·M A McLaughlin, G C Chiou
Dec 17, 1998·Ophthalmology·M M AbreuP A Netland
Apr 4, 2014·Biological & Pharmaceutical Bulletin·Irhan Ibrahim Abu HashimHidetoshi Arima
Dec 1, 1979·The British Journal of Ophthalmology·P J AiraksinenE A Jaanio
Jul 2, 1979·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·M Ober, A Scharrer

Related Concepts

Clinical Trials
Double-Blind Method
Physiologic Intraocular Pressure
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