Topical betamethasone 17-valerate is an anticorticosteroid in the rat. 1. Dermal atrophy

The British Journal of Dermatology
J M YoungB M Wagner

Abstract

In the albino rat, topical betamethasone 17-valerate acts as an anticorticosteroid. This steroid is inactive in a dermal atrophy assay over a dose range where betamethasone and hydrocortisone display atrophogenic activity. At appropriate concentrations betamethasone 17-valerate competitively inhibits the atrophogenic effects of both betamethasone and triamcinolone acetonide. Since betamethasone and betamethasone 17-valerate penetrate rat skin in vivo at essentially the same rate, it is concluded that the latter compound is relatively resistant to hydrolysis during penetration, and that it binds to rat corticosteroid receptor proteins in such a manner as to prevent expression of corticosteroid activity. Therefore, the rat cannot be used as a model species to predict activity in man for this compound.

References

Sep 1, 1977·The Journal of Investigative Dermatology·P J Dykes, R Marks
Nov 1, 1977·The Journal of Investigative Dermatology·J M YoungB M Wagner
Mar 1, 1976·The British Journal of Dermatology·J D Kirby, D D Munro
Jun 14, 1972·Journal of Molecular Biology·G G RousseauG M Tomkins
Nov 1, 1972·The American Journal of Medicine·D FeldmanI S Edelman

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Citations

Aug 4, 1992·Biochemical Pharmacology·F CabréG Carganico
Nov 1, 1979·The British Journal of Dermatology·P J Dykes, R Marks
May 13, 2006·Experimental Dermatology·Stefanie SchoepeKhusru Asadullah
Aug 6, 2019·British Journal of Pharmacology·Imke Rudnik-JansenLaura B Creemers

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