Topical calcipotriene in combination with UVB phototherapy for psoriasis

International Journal of Dermatology
D Hecker, M Lebwohl

Abstract

A total of 20 patients with symmetric plaque-type psoriasis were recruited for a controlled, investigator-blinded, right-left study. None of the patients had used any therapy other than emollients for 2 months prior to starting in the trial. All patients had a negative antinuclear antibody. By history, all patients had previously improved upon exposure to sunlight or ultraviolet light. Two symmetrical sites of equal severity were selected as target areas. Each patient was treated on one side with mineral oil twice daily and on the opposite side with calcipotriene 0.005% ointment twice daily. The investigator was blinded as to which site received which topical treatment. Both sides were treated with equal doses of ultraviolet B (UVB) three times weekly in graduated suberythemogenic doses. Ultraviolet B radiation was emitted by a group of 6-ft fluorescent bulbs (Light Sources FS72 T12 UVB HO) in a standard phototherapy unit. The above regimen was continued for a total of 12 weeks. The severity of psoriasis in the target sites was rated by the examiner at baseline and at weekly intervals for the 12 weeks of study. Target sites were rated by severity of erythema, scaling, plaque elevation, and pruritus, with each of these parameter...Continue Reading

Citations

Feb 28, 2004·Journal of the American Academy of Dermatology·Mark LebwohlSteven R Feldman
Mar 31, 1999·Journal of Dermatological Science·K Danno
Apr 13, 2005·Acta Dermato-venereologica·H Jorn BovenschenPeter C M van de Kerkhof
Jan 6, 2010·Indian Journal of Dermatology·Rajeev Patrick DasV Ramesh
Aug 20, 2003·The Journal of Investigative Dermatology·Mark LebwohlOliver Watts
Oct 3, 2003·International Journal of Dermatology·Vikas SharmaBhushan Kumar
Dec 15, 2005·Advances in Dermatology·Joseph M Kist, Abby S Van Voorhees
Jan 8, 2000·Dermatologic Clinics·M Lebwohl
Sep 29, 2004·Dermatologic Clinics·David S Aaronson, Mark Lebwohl
Jul 18, 2000·Journal of the American Academy of Dermatology·L Guenther
Feb 13, 2013·Journal of the American Academy of Dermatology·Manuela L AsztalosJohn Koo
Sep 18, 2016·Clinics in Dermatology·Asta JuzenieneWilliam B Grant
Nov 10, 2006·The Journal of Dermatological Treatment·Daniel J PearceSteven R Feldman
Oct 9, 1998·The British Journal of Dermatology·R GläserU Mrowietz
Jan 28, 2020·Expert Opinion on Drug Safety·Mio Nakamura, John Koo
Aug 15, 2001·The British Journal of Dermatology·S Lamba, M Lebwohl

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved