Topical calcipotriol for preventive treatment of hypertrophic scars: a randomized, double-blind, placebo-controlled trial

Archives of Dermatology
Willem M van der VeerFrank B Niessen

Abstract

To evaluate the efficacy of topical application of calcipotriol to healing wounds in preventing or reducing hypertrophic scar formation and to investigate the biochemical properties of the epidermis associated with hypertrophic scar formation. Randomized, double-blind, placebo-controlled trial using the reduction mammoplasty wound-healing model. University Medical Center Groningen. Patients Thirty women who underwent bilateral reduction mammoplasty. Interventions For 3 months, scar segments were treated with either topical calcipotriol or placebo. Three weeks, 3 months, and 12 months postoperatively, the scars were evaluated and punch biopsy samples were collected for immunohistochemical analysis. No significant difference in the prevalence of hypertrophic scars was observed between the placebo- and calcipotriol-treated scars. Only scars with activated keratinocytes 3 weeks postoperatively became hypertrophic (P = .001). Topical application of calcipotriol during the first 3 months of wound healing does not affect the incidence of hypertrophic scar formation. We observed a strong association between keratinocyte activation and hypertrophic scar formation. Trial Registration trialregister.nl Identifier: NTR1486.

Citations

Nov 19, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Austin LiuDavid M Ozog
Aug 21, 2010·Journal of Biomedical Materials Research. Part a·Emily C LynamZee Upton
Apr 15, 2016·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Navid EzraAlly-Khan Somani
Mar 19, 2014·Journal of Cutaneous Medicine and Surgery·Heidi Wat, Marlene Dytoc
Jun 29, 2021·Plastic and Reconstructive Surgery·Fouad SaegJeffrey E Janis

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