Topical clonidine for neuropathic pain

The Cochrane Database of Systematic Reviews
Anna WrzosekJerzy Wordliczek

Abstract

Clonidine is a presynaptic alpha-2-adrenergic receptor agonist used for many years to treat hypertension and other conditions, including chronic pain. Adverse events associated with systemic use of the drug have limited its application. Topical use of drugs is currently gaining interest, as it may limit adverse events without loss of analgesic efficacy. Topical clonidine (TC) formulations have been investigated recently in clinical trials. The objectives of this review were to assess the analgesic efficacy of TC for chronic neuropathic pain in adults and to assess the frequency of adverse events associated with clinical use of TC for chronic neuropathic pain. We searched the Cochrane Register of Studies (CRS) Online (Cochrane Central Register of Controlled Trials (CENTRAL)), MEDLINE and EMBASE databases, reference lists of retrieved papers and trial registries, and we contacted experts in the field. We performed the most recent search on 17 September 2014. We included randomised, double-blind studies of at least two weeks' duration comparing TC versus placebo or other active treatment in patients with chronic neuropathic pain. Two review authors extracted data from the studies and assessed bias. We planned three tiers of eviden...Continue Reading

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Citations

May 13, 2017·The Cochrane Database of Systematic Reviews·Sheena DerryR Andrew Moore
Jan 16, 2020·Medicina·Valeriu ArdeleanuAnca Pantea Stoian
Jun 21, 2017·The Cochrane Database of Systematic Reviews·Janna WarendorfNicolette C Notermans
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Feb 4, 2021·Current Pain and Headache Reports·Jillian MaloneyNatalie Strand
Aug 1, 2020·Current Drug Safety·Johan RøikjerNiels Ejskjaer

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