Topical clotrimazole cream for the treatment of tinea cruris: A retrospective study

Medicine
Dan ZhaoChuan-Hua Jiao

Abstract

This retrospective study assessed the efficacy and safety of 1% topical clotrimazole cream for the treatment of patients with tinea cruris (TC).We included 86 patients with confirmed TC for the presence of fungal hyphae. Of those, 43 patients received 1% topical clotrimazole cream for a total of 4 consecutive weeks, and were assigned to an experimental group. The other 43 patients underwent 1% topical butenafine cream for a total of 2 consecutive weeks, and were allocated to a control group. The efficacy and safety were measured and analyzed after 4 weeks treatment.After treatment, patients in both groups achieved better improvements in erythema (P < .01), scaling (P < .01), itching (P < .01), and KOH-negative results (P < .01), compared with those in patients before the treatment. However, there were not significant differences in erythema (P = .61), scaling (P = .57), itching (P = .47), and KOH-negative results (P = .67) between 2 groups. In addition, no treatment-related adverse events were recorded in both groups.Both 1% topical clotrimazole and butenafine cream are found to be effective and safe for patients with TC. However, there is not significant difference in efficacy and safety between two groups.

References

May 1, 1993·Journal of the American Academy of Dermatology·B E Elewski
Apr 8, 1998·Drugs·W McNeely, C M Spencer
Sep 6, 2003·Dermatologic Clinics·Aditya K GuptaBoni Elewski
Sep 12, 2008·Mycoses·Blanka HavlickovaMarkus Friedrich
Mar 30, 2010·Clinics in Dermatology·Mahreen Ameen
Apr 9, 2016·Indian Dermatology Online Journal·Alok Kumar Sahoo, Rahul Mahajan
Aug 10, 2016·Mycopathologia·Aditya K GuptaSarah G Versteeg
Jun 28, 2019·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Julie CampbellElena Bosque
Jul 23, 2019·Fungal Genetics and Biology : FG & B·Ananta KhuranaAnuradha Chowdhary

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