Topical colloidal indocyanine green-mediated photodynamic therapy for treatment of basal cell carcinoma

Pharmaceutical Development and Technology
Maha FadelAbdullah A Alyoussef

Abstract

Indocyanine green (ICG) is a near-IR fluorescent dye with a great potential for application as photosensitizer in topical photodynamic therapy (PDT) of skin diseases. Despite its merits, its use has been hampered by its high degradation rate. Therefore, in the current article, ICG was encapsulated in a vesicular colloidal nanocarrier (transfersomes), with the aim of enhancing its therapeutic efficacy. Transfersomes were characterized for their entrapment efficiency, particle size, zeta potential, morphology, in vitro release and histopathological effect on mice skin. A pilot clinical study was conducted to test its therapeutic potential for PDT of basal cell carcinoma (BCC). Transfersomal ICG displayed particle size (∼125 nm) and a negative zeta potential (∼-31 mV). Transfersomes were also able to sustain the release of ICG >2 h. Upon incorporation of transfersomal ICG in gel form, it was found to maintain the normal histology of mice skin post-irradiation with diode laser 820 nm. Moreover, ICG transfersomal PDT achieved 80% clearance rate for BCC patients with minimal pain reported during treatment. The previous findings suggest that transfersomal nanoencapsulated ICG is a promising treatment modality for BCC.

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Citations

Aug 6, 2016·Pharmaceutical Development and Technology·Xiuming CuiGang Peng
Feb 25, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Rana AbdelgawadManal Yassin Hamza
Jun 10, 2017·Pharmaceutical Development and Technology·Ana Henriques MotaCatarina Pinto Reis
Feb 17, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Shahenda A RamezDalea M Aboel-Fadl
Sep 14, 2018·Current Drug Delivery·Sandra Sherif AmerOmaima Sammour
Jan 17, 2019·The Journal of Dermatological Treatment·Khoa Nguyen, Amor Khachemoune
Mar 26, 2020·Current Drug Delivery·Maha FadelMaha Nasr
Feb 1, 2020·International Journal of Pharmaceutics·Sandra Sherif AmerOmaima Sammour
Apr 25, 2021·Photodiagnosis and Photodynamic Therapy·Maha FadelSarah Salah Thabet
Nov 10, 2021·Pharmaceutical Development and Technology·Ghada M El-Zaafarany, Maha Nasr

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