Topical Combination of Fluorouracil and Calcipotriene as a Palliative Therapy for Refractory Extramammary Paget Disease

JAMA Dermatology
Gabriel E MolinaPeggy A Wu

Abstract

Extramammary Paget disease (EMPD), a rare intraepithelial adenocarcinoma, poses a therapeutic challenge with high postoperative recurrence rates and a limited number of effective local treatment options. To describe the use and efficacy of a topical combination of fluorouracil and calcipotriene as a palliative therapy for refractory EMPD. This retrospective case series of 3 women with recurrent, refractory EMPD was conducted at Beth Israel Deaconess Medical Center, Boston, Massachusetts and Washington University School of Medicine, St Louis, Missouri. All patients were treated with a 1:1 mixture of fluorouracil, 5%, cream and calcipotriene, 0.005%, cream or ointment. Clinical and histopathological findings. All 3 women (1 in her 50s, 2 in their 70s) presented with recurrent EMPD (vulvar, perianal, and perioral) after surgery and/or irradiation, and their EMPD was refractory to treatment with imiquimod, 5%, cream. Owing to disease progression and/or intolerable adverse effects from imiquimod, the patients began treatment with a 1:1 mixture of fluorouracil, 5%, cream and calcipotriene, 0.005%, cream. This treatment, which was well tolerated, was followed by clinical improvement in symptoms and appearance of the lesions in all 3 c...Continue Reading

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Citations

Sep 5, 2019·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·I CosgareaU Hillen
Mar 27, 2020·Diagnostic Pathology·Xiaoyan LiaoDongwei Zhang
Jan 11, 2021·Annales de dermatologie et de vénéréologie·C IsnardM Moyal-Barracco
Feb 25, 2021·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Cristian Navarrete-DechentAnthony M Rossi
Apr 15, 2020·Dermatology : International Journal for Clinical and Investigative Dermatology·Igor SnastAssi Levi
Nov 20, 2021·Current Opinion in Urology·Vikram M Narayan, Viraj A Master

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