Topical corticosteroid has no influence on inflammation or efficacy after ingenol mebutate treatment of grade I to III actinic keratoses (AK): A randomized clinical trial

Journal of the American Academy of Dermatology
Andrés Már ErlendssonM Haedersdal

Abstract

Ingenol mebutate (IngMeb) is approved for treatment of actinic keratoses (AK) and may cause unpredictable local skin responses (LSR). We sought to investigate whether IngMeb-induced LSR, pain, and pruritus could be alleviated with a topical glucocorticoid and, further, to assess efficacy, cosmetic outcome, and patient satisfaction in patients with severe photodamage. In this blinded, randomized controlled clinical trial, patients with multiple AK and field cancerization of the face or scalp were treated in 2 areas with IngMeb (0.015%) daily for 3 days. After finalized IngMeb treatment, 1 area was randomized to receive topical clobetasol propionate (0.05%) twice daily for 4 days. Assessments included LSR (0-24; days 1, 4, 8, 15, 57), pain (0-10) and pruritus (0-3; days 1-15), AK clearance (days 15, 57), and cosmetic outcome (0-3; day 57). Clobetasol propionate application had no influence on LSR (P = .939), pain (P = .500), pruritus (P = .312), or AK cure rate (P = .991). Overall, IngMeb cleared 86% of all AK lesions, exerting a therapeutic effect on all AK severity grades; cure rates were 88%, 70%, and 60% for grade I, II, and III AK, respectively. Skin texture improved significantly in remedied areas (2.0 vs 1.0; P < .001); no...Continue Reading

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Citations

Oct 8, 2008·Archives of Gerontology and Geriatrics·Elsie HuiJean Woo
Jan 18, 2017·The British Journal of Dermatology·D de BerkerB R Hughes
Oct 18, 2020·Cancers·Teodor Iulian PavelAlexandru Mihai Grumezescu
Apr 7, 2021·Journal of the American Academy of Dermatology·Daniel B EisenTodd E Schlesinger
Jun 11, 2021·Journal of the American Academy of Dermatology·Daniel B EisenTodd E Schlesinger

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