Topical cyproterone acetate treatment in women with acne: a placebo-controlled trial

Archives of Dermatology
D M GruberJ C Huber

Abstract

To evaluate the clinical and hormonal response of topically applied cyproterone acetate, oral cyproterone acetate, and placebo lotion in women with acne. Placebo-controlled, randomized study. Patients were recruited from the Institute of Endocrine Cosmetics, Vienna, Austria. Forty women with acne. Treatment with oral medication consisting of 0.035 mg of ethinyl estradiol and 2 mg of cyproterone acetate (n=12), 20 mg of topical cyproterone acetate lotion (n=12), and placebo lotion (n=16) was offered. Patients were assessed monthly for 3 months. Clinical grading according to acne severity and lesion counts as well as determinations of serum cyproterone acetate concentrations. After 3 months of therapy with topical cyproterone acetate, the decrease of mean facial acne grade from 1.57 to 0.67 was significantly better (P<.05) compared with placebo (which showed a change from 1.57 to 1.25), but not compared with oral medication (1.56 to 0.75) (P>.05). Lesion counts also decreased from 35.9 to 9.1 in the topical cyproterone acetate group compared with oral medication (45.4 to 15.5) (P>.05) and placebo (38.2 to 23.1) (P<.05). After topical cyproterone acetate treatment, serum cyproterone acetate concentrations were 10 times lower than ...Continue Reading

Citations

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