Topical delivery for the treatment of psoriasis

Expert Opinion on Drug Delivery
Amitava Mitra, Yunhui Wu

Abstract

Psoriasis is one of the most common human skin diseases. Topical therapy forms the cornerstone in the management of mild-to-moderate psoriasis. Topical therapies are also used as adjunctive to systemic therapy in moderate and severe forms of the disease. In this review, an overview of psoriasis pathogenesis, new topical medications for psoriasis, new targets and molecules, combination topical therapies and combination of topical and phototherapy is provided. Over the past decade several efficacious and acceptable treatment options have emerged from the age-old therapies. The development of sophisticated formulation options has led to an enhancement in the rate and extent of drug delivery across the skin, increasing therapeutic value and improving patient compliance. Readers will learn about monotherapy and combination topical products as well as new topical drug delivery technology to achieve optimal clinical outcomes. This review will highlight the need to generate more dermal pharmacokinetic data for better understanding of the impact of formulation change on skin pharmacokinetics to help design improved topical drug delivery systems. New topical formulations have the potential to achieve better efficacy with improved safety ...Continue Reading

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Citations

Aug 1, 2014·Expert Opinion on Drug Delivery·Rahul SonawaneSanyog Jain
Jan 20, 2015·Biotechnology Advances·Alejandro Sosnik, Maya Menaker Raskin
Dec 3, 2014·International Journal of Pharmaceutics·Maria Filipa PintoSalette Reis
Oct 4, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Maria LaptevaYogeshvar N Kalia
Nov 5, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Anjali JainWahid Khan
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Feb 16, 2020·Drug Delivery and Translational Research·Juliana Santos Rosa ViegasMaria Vitória Lopes Badra Bentley
Mar 27, 2017·Polymers·Cătălina Natalia Cheaburu YilmazCătălina Elena Lupușoru
Feb 7, 2021·International Journal of Molecular Sciences·Parinbhai ShahBozena Michniak-Kohn
Aug 27, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Isabella Luiz SuzukiMaria Vitoria Lopes Badra Bentley

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