PMID: 11332039May 3, 2001Paper

Topical delivery of retinoids counteracts the UVB-induced epidermal vitamin A depletion in hairless mouse

Photochemistry and Photobiology
Christian TranJ H Saurat

Abstract

UVB irradiation depletes all-trans-retinol (ROL) and all-trans-retinyl esters (RE) from the hairless mouse epidermis. Prevention of this may be of relevance in counter-acting the long-term side effects of UVB exposure. We studied the effects of a topical treatment with natural retinoids before and after UVB exposure on three parameters involved in vitamin A metabolism: the amount of epidermal ROL and RE, the level of functional cellular retinol-binding protein I (CRBP-I), which is likely to protect ROL from UVB, as well as the cytosolic and microsomal enzyme activities which generate ROL and RE, i.e. all-trans-retinaldehyde (RAL) reductase, acylCoA:retinol acyltransferase (ARAT) and retinyl-ester hydrolase (REH). Topical pretreatment with retinoids promoted a dramatic increase of epidermal ROL, RE and CRBP-I levels, a transient increase of RAL reductase and ARAT activities as well as a decreased activity of REH, indicating a direction of epidermal vitamin A metabolism toward storage. In untreated mice UVB irradiation induced a depletion of epidermal ROL and RE in 10 min and a 50% decrease of CRBP-I after 24 h. In mice treated with topical retinoids, and then exposed to UVB, epidermal RE levels were higher than in vehicle-treate...Continue Reading

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Citations

Feb 28, 2004·Journal of the American Academy of Dermatology·Shelley Sekula-GibbsLaura Otillar
Apr 23, 2005·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·P P FuP C Howard
Feb 23, 2005·Dermatology : International Journal for Clinical and Investigative Dermatology·Christian TranJean-Hilaire Saurat
Jan 8, 2004·The Journal of Investigative Dermatology·Christophe AntilleJean-Hilaire Saurat
Oct 19, 2007·The Journal of Investigative Dermatology·Olivier SorgJean-Hilaire Saurat
Apr 20, 2012·The British Journal of Dermatology·S MaginaM A Vieira-Coelho
Dec 16, 2006·Journal of Cosmetic Dermatology·Olivier SorgJean-Hilaire Saurat
Oct 4, 2006·Dermatologic Therapy·Olivier SorgJean-Hilaire Saurat
Mar 5, 2002·The Journal of Investigative Dermatology·Olivier SorgJean-Hilaire Saurat
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