PMID: 9431711Feb 12, 1998Paper

Topical diclofenac/hyaluronic acid gel in the treatment of solar keratoses

The Australasian Journal of Dermatology
L E McEwan, J G Smith

Abstract

A randomized double-blind controlled trial of 130 patients was performed to study the efficacy and tolerability of topical 3% diclofenac in 2.5% hyaluronic acid (HA) gel (active) versus gel containing 2.5% HA alone (control) in the treatment of solar keratoses. Patients were asked to apply trial gel to the target lesion twice a day and also sunscreen once a day for 24 weeks. The complete response rates were 29% for the active gel and 17% for the control gel. The difference was not statistically significant (P = 0.14). A high percentage of patients in both groups experienced a partial response to treatment (38% active, 45% control) but there was no significant difference in the spectrum of response between the two treatments (P = 0.18). Local adverse reactions occurred significantly more frequently in patients using the active gel (29% compared to 5% using control gel, P = 0.0002).

References

Oct 14, 1993·The New England Journal of Medicine·S C ThompsonR Marks
Aug 1, 1996·The Australasian Journal of Dermatology·D W Tong, R S Barnetson

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Citations

Apr 13, 2007·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·U R Hengge
Feb 14, 2002·The British Journal of Dermatology·J K RiversY Poulin
Aug 2, 2007·Chemical & Pharmaceutical Bulletin·María Magdalena JiménezAlain Ramírez
Oct 29, 2005·Drug Delivery·Yong-Hong LiaoMarc B Brown
May 27, 2015·Advances in Therapy·Erkki J SoiniKari Saarinen
Nov 5, 2016·Actas dermo-sifiliográficas·T Gracia-CazañaY Gilaberte
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Aditya K GuptaWilliam Brintnell
Oct 2, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Maryam AsgariMary-Margaret Chren
May 31, 2007·The Australasian Journal of Dermatology·Cara HolmesAlvin H Chong
Apr 29, 2005·Journal of the European Academy of Dermatology and Venereology : JEADV·M B Brown, S A Jones
Jul 9, 2002·International Journal of Dermatology·Craig N Burkhart, Craig G Burkhart
Feb 13, 2020·Deutsches Ärzteblatt International·Ralf GutzmerCarola Berking
Apr 10, 2021·Expert Opinion on Drug Safety·Elias A T KochMarkus V Heppt
Apr 7, 2021·Journal of the American Academy of Dermatology·Daniel B EisenTodd E Schlesinger
Jun 11, 2021·Journal of the American Academy of Dermatology·Daniel B EisenTodd E Schlesinger

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