Topical drug treatment in acne

Dermatology : International Journal for Clinical and Investigative Dermatology
Harald P M Gollnick, M Schramm

Abstract

The main part of acne treatment uses the topical route. More than 50% of acne patients belong to the group presenting with acne comedonica and papulopustulosa. Whenever small nodes or scarring occur, systemic comedication is indicated, however. Topical treatment affects at least three of the four main pathogenetic factors responsible for the development of acne, i.e. hyperseborrhea, hyperkeratosis, microbial colonization and inflammation. The agents currently available influence at least one of these factors but often have additional properties. Those which act in a comedolytic and anticomedogenic manner are the retinoids tretinoin, isotretinoin, adapalene and tazarotene and azelaic acid as well, some of the retinoids having additional anti-inflammatory potency. Azelaic acid has strong antibacterial potency without inducing bacterial resistance similar to benzoyl peroxide. Unfortunately, bacterial resistances are beginning to emerge as a significant problem. Propionibacterium acnes resistance to the commonly used erythromycin can also be transferred to clindamycin, whereas no resistance has been reported to nadifloxacin so far. Today, more and more evidence comes up that topical antiandrogenic agents will soon be available to t...Continue Reading

Citations

Feb 14, 2002·Advances in Therapy·R L RizerM Jarratt
Aug 16, 2000·Pediatric Clinics of North America·D P Krowchuk
Jul 19, 2000·Enzyme and Microbial Technology·K D GreenJ M Woodley
Feb 21, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Amnon C SintovDov Tamarkin
Dec 20, 2002·Clinics in Dermatology·Marcia Ramos-e-SilvaAna Libia Cardozo Pereira
Apr 1, 2000·Clinics in Dermatology·A D Katsambas, E Nicolaidou
May 16, 2013·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Catarina Pinto ReisLia Ascensão
Feb 15, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·H Gollnick
Apr 20, 2001·Journal of Applied Microbiology·S AmrB Forbes
Apr 9, 2005·The New England Journal of Medicine·William D James
Oct 13, 2006·Current Opinion in Infectious Diseases·E Ingham
Aug 8, 2006·Postgraduate Medical Journal·J Ayer, N Burrows
Nov 11, 2003·Clinical Pharmacokinetics·Andrea Krautheim, Harald Gollnick
Oct 16, 2004·Drugs·Brigitte Dreno
Jun 19, 2002·American Journal of Clinical Dermatology·Gregory T Warner, Greg L Plosker
Apr 2, 2014·TheScientificWorldJournal·Amber VyasBina Gidwani
Jun 21, 2007·Journal of Microencapsulation·Gisele A CastroLucas A M Ferreira
Dec 24, 2005·Pharmaceutical Development and Technology·Elisabetta GaviniPaolo Giunchedi
Oct 22, 2008·Expert Opinion on Pharmacotherapy·M Badawy Abdel-Naser, C C Zouboulis
Jun 6, 2008·Expert Opinion on Drug Delivery·Gisele A Castro, Lucas Am Ferreira
Jan 19, 1999·Journal of the European Academy of Dermatology and Venereology : JEADV·H Gollnick, M Schramm
Jul 7, 2009·Bioresource Technology·R S PinhoS I Silva
Feb 10, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Naoto YamaguchiMitsunori Ono
Apr 24, 2009·The Journal of Investigative Dermatology·Teruaki NakatsujiChun-Ming Huang
Nov 6, 2008·Dermatologic Clinics·Emil A Tanghetti, Karl F Popp
Jul 28, 2007·Journal of the American Academy of Dermatology·Diane M ThiboutotUNKNOWN Adapalene-BPO Study Group
May 30, 2003·The Journal of Dermatology·Kabir Sardana, Virendra N Sehgal
Mar 1, 2014·International Journal of Cosmetic Science·B Bergler-Czop
Nov 24, 2004·Clinics in Dermatology·Andrea Krautheim, Harald P M Gollnick
Jan 31, 2006·Journal of the American Academy of Dermatology·Diane ThiboutotUNKNOWN Adapalene Study Group
Apr 26, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sang-Chul ShinKyu-Ho Yang
Aug 17, 2014·Journal of the American Academy of Dermatology·Kyle B BartlettSteven R Feldman
Feb 14, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·M T LecciaB Dreno
Apr 22, 2015·American Journal of Clinical Dermatology·Mollie D OudenhovenDean S Morrell
May 14, 2011·Postgraduate Medicine·Peter HsuRobert T Brodell

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