Topical epiregulin enhances repair of murine excisional wounds

Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
Bradley K DraperL B Nanney

Abstract

Epiregulin is a broad specificity epidermal growth factor family member that activates ErbB1 and ErbB4 homodimers and all possible heterodimeric ErbB complexes. Our objective was to determine whether topical epiregulin enhanced repair of murine excisional wounds. Wounds were treated on days 0-4 with either topical epiregulin (1 micro g/ml), epidermal growth factor (10 micro g/ml), or vehicle. At day 5 postinjury, wounds receiving epiregulin were significantly smaller than those treated with epidermal growth factor or vehicle. Treatment with epiregulin promoted greater epidermal proliferation and thickening than epidermal growth factor or vehicle due to an expansion of the proliferative compartment of keratinocytes. Dermal thickness was also increased in epiregulin-treated wounds as compared to those treated with epidermal growth factor or vehicle. In day 5 wounds, matrix metalloproteinase-3 (stromelysin-1) mRNA levels were significantly lower in epiregulin- or epidermal growth factor-treated wounds than in vehicle-treated controls, suggesting that growth factor-treated wounds were more mature and required less ongoing proteolytic activity than their same-day vehicle-treated counterparts. This is the first report that topical ep...Continue Reading

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Citations

Feb 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Shaowei LiThomas N Darling
Oct 31, 2006·The Journal of Investigative Dermatology. Symposium Proceedings·Lillian B NanneyJeffrey M Davidson
Nov 25, 2006·The Journal of Investigative Dermatology·Martina I OkwuezeLillian B Nanney
Aug 5, 2003·Journal of Cellular Biochemistry·Bradley K DraperLillian B Nanney
May 7, 2015·Advances in Wound Care·Mark A Seeger, Amy S Paller
Oct 18, 2018·Journal of Wound Care·Majana Tomic-CanicHans Smola
Oct 26, 2011·Journal of Biomaterials Science. Polymer Edition·Filippo RenòMario Cannas

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