Topical Fluoride to Prevent Root Caries: Systematic Review with Network Meta-analysis.

Journal of Dental Research
J ZhangE C M Lo

Abstract

The aim of this systematic review and network meta-analysis was to summarize the direct and indirect clinical evidence on the effectiveness of professionally applied and self-applied topical fluorides in preventing dental root caries. Controlled clinical trials with any follow-up duration were included. MEDLINE, PubMed, Embase, Scopus, and Cochrane Library were searched. Two reviewers independently carried out the selection of studies, data extraction, risk-of-bias assessments, and assessment of the certainty in the evidence using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. Fixed effects model and frequentist approach were used in the network meta-analyses. Nine clinical trials involving 4,030 participants were included. Five professionally applied and 7 self-applied topical fluoride agents or combinations were included in the meta-analyses. Compared to control group, 38% silver diamine fluoride solution, 5% sodium fluoride varnish, and 1.2% acidulated phosphate fluoride reduced root caries increment after 2 y (ranging from 0.59 to 0.85 mean decayed or filled root [DF-root]). Fluoride mouth rinse and fluoride toothpaste, used alone or in combination, reduced root caries increment aft...Continue Reading

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Citations

Jun 26, 2020·Australian Dental Journal·Kostas Kapellas, Kaye F Roberts-Thomson
Jun 27, 2020·International Journal of Molecular Sciences·Ana Gil-Bona, Felicitas B Bidlack
Mar 19, 2021·Dental Materials Journal·Motoi TakahashiJunji Tagami
May 29, 2021·British Dental Journal·Raísa CasteloBrigitte Grosgogeat
Jun 27, 2021·Journal of Dentistry·Mariele VertuanAna Carolina Magalhães

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Software Mentioned

ProQuest
Cochrane RoB
GRADE
Stata
Ovid

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