Abstract
Congenitally or early impaired skin barrier as the first event starting the 'atopic march' in atopic dermatitis (AD) patients can increase allergen penetration that results in sensitization, even in the airways, followed by asthma and allergic rhinitis. Thymic stromal lymphopoietin (TSLP) is a cytokine existing in high levels in AD skin and is considered as a novel therapeutic target for atopic disease. We generated oxazolone (Ox)-induced AD-like (Ox-AD) hairless mice and divided them into four groups according to the therapeutic challenges: topical glucocorticoid, pimecrolimus, emollient, and control (acetone-only treated). We assessed the functional studies of skin barrier, epidermal expressions of differentiation markers, IL-1α, TNF-α, proteinase-activated receptor-2 (PAR-2), TSLP and antimicrobial peptides (AMP), and serum IgE in each group. Topical glucocorticoid or pimecrolimus treatment improved AD-like skin lesions and barrier functions, and restored the epidermal expression of differentiation markers, IL-1α, TNF-α, PAR-2, and TSLP, in Ox-AD mice. The improvement was relatively better with the glucocorticoid than pimecrolimus. Epidermal AMP expression was restored by topical glucocorticoid, but not pimecrolimus. Our res...Continue Reading
References
Aug 1, 1992·The Journal of Clinical Investigation·L C WoodK R Feingold
Mar 23, 1999·Nature·T M CocksJ D Moffatt
Sep 5, 2002·Nature Reviews. Molecular Cell Biology·Mark E Fortini
Oct 11, 2002·The New England Journal of Medicine·Peck Y OngDonald Y M Leung
Jul 4, 2003·The Journal of Investigative Dermatology·Josef G MeingassnerAssadollah Bavandi
Dec 6, 2003·The Journal of Allergy and Clinical Immunology·Jonathan M Spergel, Amy S Paller
Jan 25, 2006·The Journal of Experimental Medicine·Yong-Jun Liu
Aug 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Mei LiPierre Chambon
Jan 24, 2007·The Journal of Experimental Medicine·Zoulfia AllakhverdiGuy Delespesse
Feb 27, 2007·The Journal of Allergy and Clinical Immunology·Susanne EbnerNikolaus Romani
Aug 3, 2007·The Journal of Investigative Dermatology·Mao-Qiang ManPeter M Elias
Oct 19, 2007·The Journal of Investigative Dermatology·Karin M AbergPeter M Elias
Dec 18, 2007·Modern Rheumatology·Tetsuro OzawaAtsuhito Nakao
May 30, 2008·PLoS Biology·Shadmehr DemehriRaphael Kopan
Aug 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Rui HeRaif S Geha
Mar 24, 2009·Journal of Dermatological Science·Mohammad Maged Y El-BatawyVanessa Suzan G A Hafez
May 6, 2009·The Journal of Experimental Medicine·Anaïs BriotAlain Hovnanian
May 7, 2009·Allergy·T A LeH Ogawa
Jun 6, 2009·The Journal of Investigative Dermatology·Michael J CorkSimon J Ward
Jun 27, 2009·PLoS Biology·Shadmehr DemehriRaphael Kopan
Jun 30, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hideaki KouzakiHirohito Kita
Feb 23, 2010·PloS One·Alexis DumortierFreddy Radtke
Mar 20, 2010·Nature Immunology·Steven F Ziegler, David Artis
Apr 2, 2010·International Archives of Allergy and Immunology·Tuan Anh LeKo Okumura
May 4, 2010·Dermato-endocrinology·Bodo C Melnik
May 7, 2010·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Eun Byoul LeeKyu-Earn Kim
Aug 13, 2010·The Journal of Investigative Dermatology·Anaïs BriotAlain Hovnanian
Nov 26, 2010·The Journal of Investigative Dermatology·Ye-Jin JungEung Ho Choi
Jan 6, 2011·Development·Silvio WeberPaul Saftig
Jan 27, 2011·PloS One·Hsien-Yi LinLiang-Tung Yang
Jun 3, 2011·The Journal of Investigative Dermatology·Yutaka HatanoSakuhei Fujiwara
Nov 1, 1997·Environmental Toxicology and Pharmacology·R L BergmannK E Bergmann
Jan 31, 2012·Immunity·Aditya MurthyRama Khokha
Feb 23, 2012·Mucosal Immunology·H HanS F Ziegler
May 9, 2012·The Journal of Experimental Medicine·Claus-Werner FranzkeCarl P Blobel
May 12, 2012·Annals of Dermatology·Hae-Jin LeeEung Ho Choi
May 16, 2012·European Journal of Immunology·Yanlu ZhangBaohua Zhou
May 24, 2014·Acta Dermato-venereologica·Bodo C Melnik
Jun 4, 2014·Experimental Dermatology·Bodo C Melnik
Citations
Jul 1, 2015·Archives of Dermatological Research·Sang Eun LeeSeung Hun Lee
May 5, 2016·BioMed Research International·Marina Jovanović, Zoran Golušin
Dec 3, 2016·Annals of Dermatology·Noo Ri LeeEung Ho Choi
Oct 13, 2017·International Journal of Molecular Sciences·Tzu-Kai LinJuan Luis Santiago
Sep 6, 2018·Immunopharmacology and Immunotoxicology·Na-Ra HanHyun-Ja Jeong
Feb 7, 2019·Immunopharmacology and Immunotoxicology·Xiaoxue JiangYuyang Zhang
Jan 30, 2019·Dermatologic Therapy·Griffin R LeeVivian Y Shi
Apr 12, 2019·Experimental Dermatology·Mason Henehan, Anna De Benedetto
Jul 10, 2019·Experimental Dermatology·Takamichi KakeNoriko Takahashi
Feb 11, 2021·Journal of Clinical Medicine·Justin ChoiMadan M Kwatra
Dec 29, 2020·Experimental Dermatology·Amos GilharRalf Paus