PMID: 9536549Apr 16, 1998Paper

Topical glyceryl trinitrate: a possible treatment for cutaneous leishmaniasis

Clinical and Experimental Dermatology
B ZeinaS al-Assad

Abstract

The treatment of cutaneous leishmaniasis (CL) is difficult in both the old and new worlds. However, nitric oxide (NO) is involved in host cell mediated immune responses against intracellular parasites such as Leishmania major, and both in vitro and in vivo immunological studies indicate that Leishmania parasite killing by macrophages is mediated by this substance. Glyceryl trinitrate (GTN) is an exogenous NO donor; we have successfully treated a young man with cutaneous leishmaniasis with topical GTN. We believe this to be the first reported use of GTN in the treatment of human CL.

Citations

Mar 20, 2010·Applied Microbiology and Biotechnology·Mitchell Lawrence JonesSatya Prakash
Aug 4, 2010·Applied Microbiology and Biotechnology·Mitchell Lawrence JonesSatya Prakash
May 11, 2013·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Allison J Kutner, Adam J Friedman
Jul 28, 2004·Nitric Oxide : Biology and Chemistry·M-M Cals-Grierson, A D Ormerod
Feb 21, 2004·Biochemical and Biophysical Research Communications·Alessio BocediPaolo Ascenzi

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