Topical hydrocortisone, clobetasol propionate, and calcipotriol do not increase photocarcinogenesis induced by simulated solar irradiation in hairless mice

Experimental Dermatology
C LercheH C Wulf

Abstract

Topical corticosteroids such as hydrocortisone-17-butyrate (HCB) and clobetasol-17-propionate (CP) and vitamin D(3) derivatives such as calcipotriol (CAL) are widely used to treat psoriasis. The immunosuppressive effects of corticosteroids make their topical use a concern for skin carcinogenicity. Few studies have assessed the effect of topical corticosteroids and topical vitamin D(3) derivatives on photocarcinogenesis induced by ultraviolet radiation. We investigated whether HCB, CP, or CAL can accelerate photocarcinogenesis using simulated solar radiation (SSR). HCB, CP, or CAL was applied topically to the backs of hairless, female, C3.Cg/TifBomTac-immunocompetent mice in 16 groups of 25 mice each. The drugs were applied three times weekly followed by 0, 2, 4, or 6 standard erythema doses (SED) of SSR for 365 days or until death. No change was observed in the time required for tumor development in mice treated with HCB and 2 SED (HCB-2SED) and HCB-6SED. However, the time required for tumor development increased with HCB-4SED treatment. Treatment with CP-2SED did not change the time to onset of the first and second tumor, but all other CP treatments in combination with SSR increased the time. CAL-2SED decreased the time to ons...Continue Reading

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Citations

Apr 2, 2013·Archives of Dermatological Research·Catharina M LercheHans Christian Wulf
Apr 19, 2013·Archives of Dermatological Research·Bryan Hudson HossyNádia Campos de Oliveira Miguel
Jan 4, 2012·Photodermatology, Photoimmunology & Photomedicine·Catharina M LercheHans Christian Wulf
Sep 29, 2012·Photodermatology, Photoimmunology & Photomedicine·Catharina Margrethe LercheHans Christian Wulf
Jun 9, 2016·Annals of Dermatology·Ji Seok KimSeung Phil Hong
Dec 21, 2017·International Journal of Molecular Sciences·Catharina M LercheHans Christian Wulf
Jan 2, 2015·Acta Crystallographica. Section E, Structure Reports Online·Yu ZhuHai-Li Wang
Mar 6, 2015·Experimental Dermatology·Ana TiganescuWalter M Holleran

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