Topical Imiquimod as a Treatment Option for Nodular Basal Cell Carcinoma: A Systematic Review.

Journal of Cutaneous Medicine and Surgery
Christina M Huang, Mark G Kirchhof

Abstract

Surgical excision is considered standard treatment for nodular basal cell carcinoma (nBCC). However, patients who reject or are unsuited for surgery may benefit from imiquimod (IMQ) 5% cream as an alternative treatment. The objective of this study was to conduct a systematic review on the efficacy and safety of IMQ for the treatment of nBCC. The terms basal cell carcinoma AND imiquimod OR Aldara were searched on Ovid-MEDLINE, EMBASE, and Cochrane Library databases. Articles were included if they reported the efficacy or side effects of IMQ for nBCC. Primary outcomes included clearance (clinical and histological), recurrence rates, and adverse events. Number of lesions/subjects, treatment regimens, length of treatment, and time to recurrence were secondary outcomes. Thirty-nine publications, totaling 738 lesions, revealed a 77.4% (335/433 lesions) clinical and 72.9% (390/535 lesions) histological clearance rate. Regimens ranged from once daily 2 days a week to twice daily 7 days a week. Average treatment duration was 8.81 (±3.49) weeks. There was a 1.80% recurrence rate after an average follow-up period of 13.03 (±15.09) months. Common adverse effects included erythema (77.2%), crusting (50.5%), pruritus (34.1%), tenderness/irri...Continue Reading

References

Sep 1, 1995·Journal of Leukocyte Biology·T L TestermanM A Tomai
Apr 29, 1998·Antimicrobial Agents and Chemotherapy·K R BeutnerK A Schmitt
Feb 24, 2001·Acta Dermato-venereologica·P HelmboldU F Haustein
Sep 25, 2002·Journal of the American Academy of Dermatology·Edward CowenAnthony A Gaspari
Oct 4, 2003·BMJ : British Medical Journal·C S M WongJ T Lear
Mar 11, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Amy HuberRex A Amonette
Mar 12, 2004·The Journal of the American Board of Family Practice·Mark H EbellMarjorie Bowman
Apr 30, 2004·Clinical and Experimental Dermatology·D Vidal, A Alomar
Sep 7, 2004·Clinical and Experimental Dermatology·D VidalA Alomar
Apr 2, 2005·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·J AllaliG Renard
Jul 21, 2005·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Chelsy L MartyJohn S Walsh
Oct 13, 2005·Southern Medical Journal·Yuchi C ChangStephen Tyring
Dec 27, 2005·American Journal of Ophthalmology·Maria Antonietta BlasiEmilio Balestrazzi
Jan 27, 2007·The Cochrane Database of Systematic Reviews·F J Bath-HextallH C Williams
Feb 21, 2007·Archives of Dermatology·David VidalAgustín Alomar
Mar 9, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Raveewan ChoontanomTobias Stupp
Jun 29, 2007·Acta Dermato-venereologica·Fie Saabye BøgelundRobert Gniadecki
Sep 16, 2008·Pediatric Dermatology·Amit Kumar MalhotraKaushal K Verma
Dec 23, 2009·Archives of Dermatology·W Elliot LoveJeremy S Bordeaux
Mar 23, 2010·Ophthalmic Plastic and Reconstructive Surgery·Rachel Camargo CarneiroSuzana Matayoshi
May 21, 2010·Dermatology : International Journal for Clinical and Investigative Dermatology·T WetzigU Paasch
Aug 12, 2010·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Elena Garcia-MartinJavier Fernandez
Oct 5, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Verena ProkoschTobias Stupp
Jan 19, 2011·The British Journal of Ophthalmology·E Garcia-MartinF J Fernandez
Nov 15, 2012·Journal of Cutaneous Medicine and Surgery·Lauren LaBergeAdam J Mamelak
Jan 9, 2013·Dermatology : International Journal for Clinical and Investigative Dermatology·A M Skaria
Dec 18, 2013·The Lancet Oncology·Fiona Bath-HextallUNKNOWN Surgery versus Imiquimod for Nodular Superficial basal cell carcinoma (SINS) study group
Mar 4, 2014·Current Dermatology Reports·Shalini V Mohan, Anne Lynn S Chang
Apr 18, 2015·BMC Ophthalmology·Erick Marcet Santiago de MacedoSuzana Matayoshi
Nov 6, 2015·Acta Dermato-venereologica·Isabelle MartinWiebke K Peitsch
Jul 9, 2016·International Journal of Dermatology·Edith HannaOssama Abbas

❮ Previous
Next ❯

Citations

Oct 7, 2021·Immunity, Inflammation and Disease·Haiyan YuOliver Seifert

❮ Previous
Next ❯

Software Mentioned

Ovid

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.