PMID: 9419021Jan 7, 1998Paper

Topical immune modulation (TIM): a novel approach to the immunotherapy of systemic disease

Immunology Letters
R B StrickerW L Epstein

Abstract

In this article, we present the concept of topical immune modulation, or TIM. TIM is based on the observation that skin contact sensitizing agents such as poison ivy, poison oak and dinitrochlorobenzene (DNCB) are potent stimulants of the cellular immune system that combats viruses and other pathogens. We discuss the evolution of DNCB as a therapeutic modality in the acquired immunodeficiency syndrome (AIDS) and we explore the mechanism by which DNCB directs the immune response. The potential use of topical immune modulators in autoimmune disease and vaccine development is also delineated. TIM represents a novel approach to immunotherapy that should have widespread application for immunologic diseases.

References

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Citations

Aug 30, 2000·Immunology Letters·B GoldbergR B Stricker
Feb 27, 2001·Immunology Letters·R B Stricker, E E Winger
Nov 30, 1999·Immunology Letters·B Goldberg, R B Stricker
Sep 3, 2011·Journal of Dermatological Case Reports·Leena ChularojanamontriWoraphong Manuskiatti
Nov 21, 2000·Lancet·R De Lancie
Mar 22, 2000·Journal of the American Academy of Dermatology·L B MillsW L Epstein

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