Topical insulin application improves healing by regulating the wound inflammatory response

Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
Xuelian ChenXiong Zhang

Abstract

Inflammation, the initiating stage of wound healing, is characterized by increased endothelial permeability, infiltration of inflammatory cells, and secretion of numerous growth factors and chemokines. By controlling wound contamination and infection, as well as inducing the repairing process, inflammatory response plays an irreplaceable role during wound healing. We utilized a variety of approaches to observe the effect of insulin on wound inflammatory response, specifically the effect of insulin on the function of wound macrophages. We also investigated whether insulin-regulated inflammatory response contributed to insulin-induced healing. Mice excisional wounds treated with insulin showed advanced infiltration and resolution of macrophages, which correlated with the expression of monocyte chemotactic protein-1, a potent chemotactic factor for macrophages. Blockage of monocyte chemotactic protein-1 resulted in reduced macrophages infiltration and impaired wound healing despite the presence of insulin. In vitro studies showed insulin-facilitated monocytes/macrophages chemotaxis, pinocytosis/phagocytosis, and secretion of inflammatory mediators as well. Our study strongly suggests that insulin is a potent healing accelerant. Re...Continue Reading

References

Jan 1, 1968·Archives of Surgery·S P Rosenthal
Dec 1, 1994·European Journal of Immunology·P AllavenaA Mantovani
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·I F CharoS R Coughlin
Jan 1, 1997·The International Journal of Biochemistry & Cell Biology·S O'Kane, M W Ferguson
Mar 14, 1998·The Journal of Trauma·E J PierreD N Herndon
Sep 2, 1999·The New England Journal of Medicine·A J Singer, R A Clark
Aug 11, 2000·Chest·C A Dinarello
May 15, 2001·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·L A DipietroR L Gamelli
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
May 1, 1965·Journal of Dental Research·W B GREGORY
Apr 17, 2004·The Journal of Investigative Dermatology·Randle M GallucciSijy J O'Dell
Feb 15, 2005·Experimental Cell Research·Massimo M Santoro, Giovanni Gaudino
Oct 6, 2005·Trends in Cell Biology·Paul Martin, S Joseph Leibovich
Nov 22, 2005·Clinical and Experimental Immunology·F PorcherayG Gras
Dec 20, 1928·The Journal of Physiology·L KingA Piney
Aug 1, 1930·Annals of Surgery·B Joseph
Nov 15, 2007·Biochemical and Biophysical Research Communications·Kai KappertPhilipp Stawowy
Oct 3, 2008·Gynecologic Oncology·Marie N MenkeRobert F Diegelmann
Jan 9, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Stephan BarrientosMarjana Tomic-Canic
Jul 16, 2009·Journal of Cellular and Molecular Medicine·Yan LiuManuela Martins-Green
Oct 24, 2009·The American Journal of Pathology·Rita MirzaTimothy J Koh
Feb 24, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tina LucasSabine A Eming
Jun 26, 2010·Journal of the American Academy of Dermatology·Stephan SchremlPhilipp Babilas
Feb 23, 2011·The Journal of Pathology·Ping LiYuan-Guo Zhou

❮ Previous
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Citations

Nov 20, 2012·Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India·Sujata Sarabahi
Feb 25, 2014·Life Sciences·Thatiana L Assis de BritoBruna Romana-Souza
Jan 23, 2016·Journal of Diabetes and Its Complications·Jay J SalazarTimothy J Koh
Jan 8, 2014·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Enas A S AttiaManal H El Hamamsy
Jul 24, 2014·Acta histochemica·Aline Donato-TrancosoBruna Romana-Souza
Jun 10, 2015·The Journal of Experimental Medicine·Soung-Hoon LeeKang-Yell Choi
Oct 28, 2014·Clinical Oral Investigations·A Harika Kutluay KöklüDilek A Uğar Çankal
Sep 23, 2016·Archives of Dermatological Research·T EmanuelliE Carvalho
Jun 27, 2015·Biological Research for Nursing·F AzevedoM H Lima
Jun 26, 2018·Journal of Peptide Science : an Official Publication of the European Peptide Society·Michelle V MouritzenHåvard Jenssen
Jul 28, 2019·Journal of Investigative and Clinical Dentistry·Naglaa M El-Wakeel, Marwa H S Dawoud
May 29, 2016·Journal of Basic and Clinical Physiology and Pharmacology·Jyoti M Benni, Paragouda A Patil
Oct 19, 2017·Journal of Maxillofacial and Oral Surgery·Shruti ChhabraNiti Gupta
Oct 5, 2016·Experimental and Therapeutic Medicine·Chejiang WangJianke Feng
Mar 17, 2021·Journal of Histotechnology·Mehri MirhoseiniFereshteh Talebpour Amiri
May 18, 2021·Frontiers in Immunology·Cesare TripolinoFrancesco Ursini

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