Topical ketamine and morphine for post-tonsillectomy pain

European Journal of Anaesthesiology
O CanbayU Aypar

Abstract

Tonsillectomy is frequently associated with postoperative pain of considerable duration, which is usually accompanied by the substantial consumption of both opioid and non-opioid analgesics. Despite the use of different surgical and anaesthetic techniques in the search for safe and effective post-tonsillectomy pain relief, this problem remains a clinical dilemma. The aim of the current study was to evaluate the potential effects of topically administered ketamine and morphine by an oral rinse into the tonsillar fossae. In all, 60 children, 15 for each group, aged between 3 and 12 yr scheduled for tonsillectomy were randomly assigned to one of four groups. Study drugs were administered to both tonsillar fossae for 5 min. Group K received 0.4 mL (20 mg) ketamine in 10 mL artificial saliva, Group KM received 0.4 mL (20 mg) ketamine + 5 mL (20 mg) 4 per thousand morphine aqueous solution in 5 mL artificial saliva, Group M received 5 mL (20 mg) 4 per thousand morphine aqueous solution in 5 mL artificial saliva, Group C received only 10 mL artificial saliva. Postoperative pain, nausea, vomiting, sedation and bleeding were evaluated. Pain scores were higher in the control group at arrival in the recovery ward (P < 0.05). Morphine and ...Continue Reading

References

Apr 1, 1982·Anesthesiology·A D Finck, S H Ngai
Sep 1, 1995·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·A K WongD W Fear
Jan 1, 1993·International Journal of Pediatric Otorhinolaryngology·J A JebelesI Kissin
Apr 1, 1996·Clinical Otolaryngology and Allied Sciences·A D Husband, A Davis
Jun 17, 1998·Brain Research·S M CarltonR E Coggeshall
Jul 17, 1998·Anesthesiology·J L PedersenH Kehlet
Feb 19, 1999·Brain Research·S M Carlton, R E Coggeshall
Jun 25, 1999·Acta Oto-laryngologica·S H NordahlH J Breidablikk
Aug 12, 1999·Anesthesiology·R KorpelaO A Meretoja
Mar 14, 2000·Acta Anaesthesiologica Scandinavica·J RømsingG Ravn
Nov 7, 2000·British Journal of Anaesthesia·H GottrupT S Jensen
Nov 1, 2001·Archives of Otolaryngology--head & Neck Surgery·C GiannoniT Morey
Feb 15, 2002·Archives of Otolaryngology--head & Neck Surgery·Nilesh Raman VasanMark Ward
Feb 28, 2002·The Journal of Laryngology and Otology·T HungN Patel
Mar 15, 2002·American Journal of Otolaryngology·Stilianos E Kountakis
Oct 10, 2002·Regional Anesthesia and Pain Medicine·Takahiro UshidaHiroshi Yamamoto
Apr 23, 2003·Neurology·Dianna QuanDonald H Gilden
Sep 17, 2003·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Neal E Slatkin, Michelle Rhiner
Apr 1, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Daniel J HallMichael R Holtel
Jan 4, 2005·International Journal of Pediatric Otorhinolaryngology·M Z NajaM A Al-Tannir
May 12, 2005·International Journal of Pediatric Otorhinolaryngology·E EgeliO Ozturk
Aug 24, 2005·Annales Françaises D'anesthèsie Et De Rèanimation·P RichebéG Simonnet
Sep 15, 2005·International Journal of Pediatric Otorhinolaryngology·M Z NajaM A Al-Tannir
Dec 13, 2005·The Clinical Journal of Pain·Reino Pöyhiä, Anneli Vainio

❮ Previous
Next ❯

Citations

Apr 23, 2013·Trends in Pharmacological Sciences·Christoph Stein, Sarah Küchler
Nov 5, 2008·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Serkan SertelPeter Karl Plinkert
Jan 11, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Hasan GaripKamil Göker
Jun 6, 2015·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Onur GönülKamil Göker
Mar 26, 2013·Paediatric Anaesthesia·Umit Y TekeliogluHasan Kocoglu
Mar 31, 2011·Paediatric Anaesthesia·Souhayl DahmaniJean Mantz
Aug 21, 2014·International Journal of Pediatric Otorhinolaryngology·Yao TongQuan Li
Sep 12, 2013·The Cochrane Database of Systematic Reviews·Zbys FedorowiczJassim H Al Langawi
Jun 19, 2009·Anesthesia and Analgesia·Deborah A SchwengelEugenie S Heitmiller
Jun 10, 2010·Current Opinion in Anaesthesiology·Jan Persson
Jun 20, 2014·Anesthesia and Analgesia·Jana Sawynok
Jul 22, 2014·Craniomaxillofacial Trauma & Reconstruction·Talal A KayyalChris D Glover
Nov 1, 2020·Pediatric Blood & Cancer·Satya PrakashRachna Seth
Jul 9, 2009·Current Opinion in Anaesthesiology

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.