Topical ketoconazole for experimental Candida keratitis in rabbits

American Journal of Ophthalmology
Y Ishibashi, H E Kaufman

Abstract

Topical ketoconazole (2% ointment three times per day for three weeks) markedly reduced the severity of keratitis produced with Candida albicans inoculation in the right eyes of 20 rabbits. Clinical scores of affected eyes were significantly lower in the treated eyes than in the controls, which consisted of the 20 inoculated but untreated left eyes of the same rabbits. All cultures of corneal scrapings from the treated eyes were negative on the 12th day after inoculation, while two cultures were still positive at the end of the experiment (day 21) in the control eyes. Histopathologic examination showed less severe inflammatory changes in the treated eyes than in the control eyes.

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Citations

Sep 23, 2008·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Junjie ZhangHuiyun Xia
Jan 1, 1990·The British Journal of Ophthalmology·W Behrens-BaumannR Rüchel

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