Topical levocabastine for the treatment of perennial allergic rhinitis

The Journal of Laryngology and Otology
S Elwany, M Bassiouny

Abstract

The ultrastructure of the nasal mucosa following the use of intranasal levocabastine was studied in 20 patients suffering from perennial allergic rhinitis. The patients received twice daily 0.05 per cent levocabastine spray with a treatment duration of four weeks. At the end of the treatment period regression of the allergic process was evidenced by progressive reappearance of normal cilia and microvilli on the columnar cells, decrease of intercellular oedema and cytoplasmic vacuoles, increased number of mucous acinar cells, gradual decrease of vascular congestion, as well as diminished oedema fluid formation. The drug, however, had no effect on mast cell degranulation nor on eosinophilic infiltration. Normalization of the ultrastructural features correlated well with clinical improvement. Considering the results of the present study, levocabastine nasal spray appears to be an effective treatment for perennial allergic rhinitis and can be used with, or as an alternative to, other anti-allergic medications.

References

Jan 1, 1976·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·H H Toppozada, M A Talaat
Jan 1, 1975·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·H H Toppozada, M A Talaat
Dec 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H Klementsson
Jan 1, 1983·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·S S Elwany, W M Stephanos
Sep 1, 1984·The Journal of Laryngology and Otology·S ElwanyW Stephanos
May 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A B Frostad, A K Olsen

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