Topical methyl-aminolevulinate photodynamic therapy using red light-emitting diode light for treatment of multiple actinic keratoses: A randomized, double-blind, placebo-controlled study

Journal of the American Academy of Dermatology
D M PariserSuzanne Bruce

Abstract

The use of light-emitting diode light offers practical advantages in photodynamic therapy (PDT) with topical methyl-aminolevulinate (MAL) for management of actinic keratoses (AK). We sought to evaluate the efficacy of MAL PDT using red light-emitting diode light. We conducted a multicenter, double-blind, randomized study. A total of 49 patients with 363 AK lesions had 16.8% MAL cream applied under occlusion for 3 hours, and 47 patients with 360 AK lesions had vehicle cream similarly applied. The lesions were then illuminated (630 nm, light dose 37 J/cm2) with repeated treatment 1 week later. Complete lesion and patient (all lesions showing complete response) response rates were evaluated 3 months after last treatment. MAL PDT was superior (P<.0001) to vehicle PDT with respect to lesion complete response (86.2% vs 52.2%, odds ratio 6.9 [95% confidence interval 4.7-10.3]) and patient complete response (59.2% vs 14.9%, odds ratio 13.2 [95% confidence interval 4.1-43.1]). The study population may not be representative of all patients with AK. MAL PDT using red light-emitting diode light is an appropriate treatment alternative for multiple AK lesions.

References

Jun 10, 2000·The British Journal of Dermatology·A A MemonP S Friedmann
Dec 24, 2005·The Journal of Investigative Dermatology·Even Angell-PetersenKarl-Erik Giercksky
Dec 28, 2006·Journal of the American Academy of Dermatology·Lasse R BraathenUNKNOWN International Society for Photodynamic Therapy in Dermatology

❮ Previous
Next ❯

Citations

May 26, 2009·Current Opinion in Otolaryngology & Head and Neck Surgery·Jacob Brodsky
Oct 15, 2013·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Kate RossNeil Fenske
Sep 3, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Haixia QiuNaiyan Huang
Nov 20, 2012·Journal of the American Academy of Dermatology·Robert BissonnetteSimon Nigen
Nov 30, 2011·Photodiagnosis and Photodynamic Therapy·Hyun-Ju Lim, Chung-Hun Oh
Jul 6, 2010·International Journal of Pharmaceutics·Anja SchwankeMonika Schäfer-Korting
Jun 15, 2010·Clinics in Dermatology·Christine J Ko
Jul 14, 2009·Journal of Photochemistry and Photobiology. B, Biology·Tim Smits, Anne C E Moor
Nov 28, 2015·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Wolfgang G Philipp-DormstonRolf-Markus Szeimies
Mar 10, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·L SchmitzT Dirschka
Dec 18, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·D-Y KoK-H Song
Mar 13, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·B DrénoUNKNOWN AKTeam™
Nov 6, 2009·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Max Schlaak, Jan C Simon
Feb 28, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Kecheng LeiJianwen Liu
May 27, 2015·Advances in Therapy·Erkki J SoiniKari Saarinen
Sep 21, 2016·Dermatology and Therapy·Rolf-Markus SzeimiesRobert Bissonnette
Nov 1, 2016·The Journal of Dermatological Treatment·Thomas DirschkaGiovanni Pellacani
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Aditya K GuptaWilliam Brintnell
Jul 13, 2018·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Piergiacomo Calzavara-PintonNeda T Tanova
Sep 6, 2018·The British Journal of Dermatology·S H IbbotsonL S Exton
Feb 19, 2020·Expert Opinion on Emerging Drugs·Philipp Cramer, Eggert Stockfleth
Apr 12, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·L SchmitzT Dirschka
May 31, 2020·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·D NashanC Berking
Jun 28, 2020·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Amanda Nascimento Cavalleiro Macedo MotaCarlos Baptista Barcaui

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.