Topical metronidazole application in recall patients. Long-term results

Journal of Clinical Periodontology
M Stelzel, L Flores-de-Jacoby

Abstract

The aim of this randomised study in split-mouth design, in which 24 patients from the recall programme of Marburg University Department of Periodontology were enrolled, was to compare topical application of a metronidazole 25% dental gel with subgingival scaling. The clinical parameters used were pocket probing depth (PPD) and bleeding on probing (BOP); these were recorded at baseline and 1, 3, 6, 14, 18 and 24 months after completion of treatment. In addition, plaque samples were taken from all mesial pockets for evaluation by dark-field microscopy. All patients had at least one tooth in each quadrant with a PPD of 5 mm or more showing BOP when they entered the study. The treatment consisted of 2 applications of dental gel in 2 randomly selected quadrants (on days 0 and 7) as well as subgingival scaling of the remaining quadrants. Statistical evaluation of all sites with a baseline PPD of 5 mm or more showed that both methods led to a significant reduction in PPD and BOP in the first 6 months. The average reduction in PPD was 1.3 mm in the gel group and 1.5 mm in the scaling group, with the tendency to bleeding being reduced by ca. 50% in both groups. After 24 months, improvements of 0.6 mm and 0.5 mm respectively were observe...Continue Reading

References

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May 1, 1992·Journal of Clinical Periodontology·H McNabbN P Lang
Oct 1, 1992·Journal of Clinical Periodontology·K Stoltze, M Stellfeld
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Citations

May 9, 1998·International Journal of Antimicrobial Agents·G L Southard, K C Godowski
Aug 7, 2004·Journal of Periodontology·Maria PaviaItalo F Angelillo
Jan 6, 2001·Journal of Clinical Periodontology·P A HeasmanG I McCracken
Sep 26, 2002·Journal of Clinical Periodontology·Giovanni E SalviNiklaus P Lang
Aug 28, 2004·Periodontology 2000·Makoto UmedaIsao Ishikawa
Aug 28, 2004·Periodontology 2000·Clay B WalkerPierre Baehni
Sep 17, 2003·Oral Diseases·E Venezia, L Shapira
Sep 17, 2003·Oral Diseases·C E Dörfer
Mar 16, 2002·Journal of Clinical Periodontology·Peter EickholzPetra Ratka-Krüger
Jul 29, 2006·The Quarterly Journal of Experimental Psychology : QJEP·Steve W Kelly, Katie Wilkin
Dec 5, 1998·Journal of Clinical Periodontology·R D Finkelman, R C Williams

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