Topical micronutrients in atopic dermatitis-An evidence-based review

Dermatologic Therapy
M MaaroufV Y Shi

Abstract

The role of dietary factors is an important and controversial topic in the pathogenesis of atopic dermatitis (AD). Despite the preponderance of consumer products utilizing oral micronutrients supplementation for relief AD symptoms, less attention has been paid on the utility of topical micronutrients, specifically for individuals with AD. We review evidence on topical formulations of vitamins (A, B, C, D, and E) and trace minerals (magnesium, manganese, zinc, and iodine) for treatment of AD. While topical B, C, and E formulations appear to provide some benefit to AD individuals, topical vitamin A has no utility, and topical vitamin D may exacerbate symptoms. Magnesium, zinc, and iodine all appear to improve AD through anti-inflammatory and anti-microbial effects, though future studies must evaluate their use as monotherapy. The exposition of the effects that topical micronutrients have on AD offers an adjuvant treatment modality for this common inflammatory dermatosis.

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Citations

Feb 26, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·N A GrayN P Khumalo
Dec 4, 2019·The British Journal of Dermatology·A J HendricksV Y Shi
Dec 15, 2018·Dermatologic Therapy·Annunziata DattolaSteven Paul Nisticò
Mar 12, 2020·Clinical Reviews in Allergy & Immunology·Chun-Min KangLi-Chieh Wang
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May 1, 2021·International Journal of Molecular Sciences·Hyunjin YeoSoon Young Shin
Sep 17, 2021·Dermatologic Therapy·Katerina DamevskaStefana Damevska

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