Topical minocycline microspheres versus topical chlorhexidine gel as an adjunct to mechanical debridement of incipient peri-implant infections: a randomized clinical trial

Journal of Clinical Periodontology
Stefan RenvertMarie Svensson

Abstract

This randomized clinical trial presents a 12-month follow-up of the clinical and microbiological results after application of minocycline microspheres as an adjunct to mechanical treatment of incipient peri-implant infections compared with an adjunctive treatment using 1% chlorhexidine gel application. Thirty-two subjects with probing depth > or =4 mm, combined with bleeding and/or exudate on probing and presence of putative pathogenic bacteria were given oral hygiene instructions and mechanical treatment of infected areas adjacent to implants. The subjects were then randomly assigned adjunctive subgingival antimicrobial treatment using either chlorhexidine gel or minocycline microspheres. Sixteen patients in the minocycline group and 14 in the chlorhexidine group completed the study. Follow-up examinations were carried out after 10 days, 1, 2, 3, 6, 9 and 12 months. The adjunctive use of minocycline microspheres resulted in improvements of probing depths and bleeding scores, whereas the adjunctive use of chlorhexidine only resulted in limited reduction of bleeding scores. For the deepest sites of the treated implants in the minocycline group, the mean probing depth was reduced from 5.0 to 4.4 mm at 12 months. This study could ...Continue Reading

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Citations

Aug 3, 2007·Journal of Periodontology·J Max GoodsonJudy Comiskey
Sep 5, 2014·Head & Face Medicine·Ralf SmeetsJamal M Stein
Dec 2, 2014·Dental Clinics of North America·Georgios E RomanosJosé Luis Calvo-Guirado
May 9, 2015·Acta Odontologica Scandinavica·Hadar HallströmSvante Twetman
Feb 16, 2016·SpringerPlus·Nisha MahatoLu Wang
Nov 6, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M GiannelliA Tani
May 15, 2008·Journal of Clinical Periodontology·Sotirios KotsovilisIoannis Fourmousis
Jan 8, 2009·Clinical Oral Implants Research·Maria Beatriz MáximoPoliana Mendes Duarte
Sep 9, 2008·Journal of Clinical Periodontology·Stefan RenvertNoel Claffey
Jun 5, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Krisztina UngváriKinga Turzó
May 26, 2012·Clinical Oral Implants Research·Andrea CochisLia Rimondini
Nov 26, 2010·Journal of Clinical Periodontology·Stefan RenvertG Rutger Persson
Jul 21, 2011·Journal of Clinical Periodontology·Georgios CharalampakisGunnar Dahlén
Oct 25, 2012·Clinical Oral Implants Research·Manoj MuthukuruThomas F Flemmig
Jul 25, 2013·International Dental Journal·Fawad JavedHoward C Tenenbaum
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Apr 9, 2015·Journal of Clinical Periodontology·Caroline Riben-GrundstromStefan Renvert
Apr 10, 2013·Acta Odontologica Scandinavica·Taner ArabaciMehmet Özgöz
Dec 18, 2016·Journal of Investigative and Clinical Dentistry·Edwin X J Goh, Lum Peng Lim
Jan 1, 2011·Pharmaceutics·Asteria Luzardo AlvarezJosé Blanco Méndez
Dec 15, 2017·Periodontology 2000·Stefan Renvert, Ioannis Polyzois

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