Topical mitomycin-C for the treatment of anal stricture

Journal of Pediatric Surgery
Claudia M MuellerDickens St-Vil

Abstract

Anal stricture is a well-known and feared consequence of anorectal surgery. Daily dilatations are often prescribed in the immediate postoperative period to avoid stricture of the anus. Nonetheless, stricture may still occur and, particularly in older children, may require multiple dilatations under anesthesia. Topical mitomycin-C has been found to be effective in the treatment of strictures at various anatomical locations. In this article, we review our experience with topical mitomycin-C as an adjunct to anal dilatation for children with anal stricture. Cases of children with anal stricture who were treated with a single application of topical mitomycin-C as an adjunct to anal dilatation between 2000 and 2008 were analyzed retrospectively. Anal diameter was measured with Hegar dilators. Cottonoid swabs soaked in mitomycin-C were placed on the anal mucosa for 5 minutes after dilatation. Treatment success was defined by sustained improvement in anal size, decrease in symptoms, parental satisfaction, and need for additional intervention. Ten children with anal stricture who underwent anal dilatation with application of topical mitomycin-C were identified. All children presented with severe constipation. Average increase in anal s...Continue Reading

References

Feb 24, 2001·The Annals of Otology, Rhinology, and Laryngology·R RahbarG B Healy
Apr 3, 2001·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·D JassirO Gomez-Marin
Jan 25, 2005·International Journal of Urology : Official Journal of the Japanese Urological Association·Ali AyyildizDemokan Erol
Feb 28, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Matthew L UbellAlbert L Merati
Oct 6, 2006·Head & Neck·M Boyd GillespieBonnie Martin-Harris
Feb 3, 2007·Journal of Pediatric Surgery·Alberto PeñaMarc Levitt
Feb 28, 2007·Journal of Pediatric Gastroenterology and Nutrition·S RosseneuM Thomson
Apr 10, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Joseph ShvidlerBenjamin Cable
Jun 15, 2007·Journal of Pediatric Surgery·Alberto PeñaMarc A Levitt
May 29, 2008·Pediatric Blood & Cancer·Pietro BetalliGiovanni Cecchetto
Jul 23, 2008·Archives of Otolaryngology--head & Neck Surgery·Rodrigo Iñiguez-CuadraRodrigo Iñiguez-Sasso

❮ Previous
Next ❯

Citations

Jan 30, 2015·Journal of Clinical Gastroenterology·Tarun RustagiLoren Laine
Feb 23, 2020·Pediatric Surgery International·Emre Divarci, Orkan Ergun
Jul 1, 2020·The Laryngoscope·Katherine C YungMark S Courey
Feb 10, 2017·Pediatric Surgery International·J C LangerUNKNOWN American Pediatric Surgical Association Hirschsprung Disease Interest Group
Jun 15, 2020·Journal of Pediatric Surgery·Zhixiong LinYifan Fang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.