PMID: 2502950Aug 1, 1989Paper

Topical mupirocin treatment of impetigo is equal to oral erythromycin therapy

Archives of Dermatology
P M MertzJ Montalvo

Abstract

Topical antimicrobial therapy has not been effective in the past against cutaneous bacterial infections. In this study, a new topical antibiotic ointment, mupirocin, was compared with oral erythromycin ethylsuccinate in the treatment of impetigo. Seventy-five patients clinically diagnosed as having impetigo and with positive cultures of Staphylococcus aureus, Streptococcus pyogenes, or both were examined in an investigator-blinded study. Patients used topical mupirocin applied three times daily or the usual oral dose of erythromycin ethylsuccinate (30 to 50 mg/kg per day). Patients' lesions were examined clinically and cultured bacteriologically on days 0, 3, and 8, and 1 week after treatment. Susceptibility testing was performed on pathogens isolated to determine antibiotic resistance. Mupirocin treatment produced similar clinical results to oral erythromycin and was superior in the eradication of S aureus, including antibiotic-resistant S aureus. These results show topical mupirocin to be a safe and effective alternative to oral antibiotic therapy in the treatment of impetigo.

Citations

Feb 15, 2001·Clinics in Dermatology·I OumeishO Bataineh
Sep 8, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Whitney J LapollaSteven R Feldman
Jan 26, 2002·BMJ : British Medical Journal·Sander KoningJohannes C van der Wouden
Jan 8, 2004·Archives of Disease in Childhood·D Dobie, J Gray
Apr 1, 1997·Journal of the American Academy of Dermatology·K L Chapel, J E Rasmussen
Dec 1, 1999·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·V Livingstone, L J Stringer
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Oct 7, 2009·Expert Review of Anti-infective Therapy·Ronald PangilinanGlenn Tillotson
Dec 20, 2005·The Journal of Dermatology·Shuichi KuniyukiShinsuke Suzuki

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