Topical nitroglycerin: a potential treatment for impotence

The Journal of Urology
J A OwenA Morales

Abstract

The effect of 2 per cent nitroglycerin paste applied to the penile shaft of impotent subjects was evaluated in a placebo controlled double-blind study under laboratory conditions. After application of nitroglycerin paste or a placebo ointment base, penile tumescence was recorded through a strain gauge transducer while subjects viewed an erotic video presentation. Relative to the placebo paste the number of subjects demonstrating an increase in penile circumference after nitroglycerin (18 of 26) was significantly different than all other outcome possibilities (p less than 0.05). Noninvasive vascular assessment by ultrasonography demonstrated an increase in diameter and blood flow in the cavernous arteries after application of nitroglycerin paste. Nitroglycerin paste increases blood flow in the cavernous arteries and improves tumescence after erotic stimulation. This agent may represent a new therapy for impotence.

References

May 1, 1987·The Journal of Urology·T F Lue, E A Tanagho
Nov 1, 1985·Annals of Internal Medicine·J D Talley, I S Crawley
Dec 1, 1980·The Journal of Urology·R S Welti, J B Brodsky
Jul 1, 1982·The Journal of Urology·A MoralesJ Fenemore
Jan 1, 1982·Journal of Psychoactive Drugs·T P Lowry
May 1, 1980·Canadian Journal of Physiology and Pharmacology·J A ArmstrongP W Armstrong
Jul 1, 1982·The Journal of Urology·A MoralesJ Fenemore

❮ Previous
Next ❯

Citations

Jan 1, 1997·International Urology and Nephrology·M BaşarZ Akalin
Aug 24, 1999·The Journal of Urology·K T McVaryR W Pelham
Nov 22, 2005·Expert Opinion on Drug Delivery·Michael Ohebshalom, John P Mulhall
Nov 12, 2002·Current Urology Reports·Ronald L Yap, Kevin T McVary
Jan 1, 1992·British Journal of Urology·H H MeyhoffA Bødker
Mar 30, 1993·Hospital Practice·A Morales
Oct 1, 1993·The Journal of Urology·B D Nunez, D C Anderson
Oct 1, 1995·Diabetes/metabolism Reviews·C F Close, R E Ryder
Sep 1, 1994·The British Journal of Surgery·P B LoderR K Phillips
Mar 16, 2000·Clinical Endocrinology·A LevyC Gingell
Apr 1, 1990·The Journal of Urology·J P HeatonJ Fenemore
Feb 1, 1995·The Journal of Urology·E D KimK T McVary
May 1, 1994·The Journal of Urology·S B RadomskiS Rangaswamy
Jan 29, 2020·Pharmacology & Therapeutics·Emma MitidieriRaffaella Sorrentino
Jan 21, 2006·The Journal of Sexual Medicine·Harin Padma-NathanClaude Teloken

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Urology
C M EarlsW L Marshall
Zhonghua yi xue za zhi = Chinese medical journal; Free China ed
K K ChenL S Chang
Archivio italiano di urologia, andrologia : organo ufficiale [di] Società italiana di ecografia urologica e nefrologica
Marchiori DeboraMartorana Giuseppe
© 2022 Meta ULC. All rights reserved