Topical Oil Application and Trans-Epidermal Water Loss in Preterm Very Low Birth Weight Infants-A Randomized Trial

Journal of Tropical Pediatrics
Sushma NangiaDeepak Chawla

Abstract

Topical emollient application reduces trans-epidermal water loss (TEWL) in preterm neonates. Coconut oil used traditionally for infant massage in India has not been evaluated for the same. Very low birth weight (VLBW) neonates were randomized at 12 h of age to Oil (n = 37) or Control (n = 37) groups. Oil group neonates received twice-daily coconut oil application without massage, and Control group received standard care. TEWL was measured every 12 h using an evaporimeter till Day 7 when skin swabs were obtained for bacterial growth and skin condition was assessed using a validated score. Birth weight (g; mean ± SD: 1213 + 214 vs. 1164 + 208, p = 0.31), gestation [week; median (interquartile range): 32 (31-33) vs. 32 (29-33), p = 0.10] and other baseline variables were comparable. TEWL was significantly reduced (g/m(2)/h, mean difference: -6.80, 95% confidence interval: -3.48, -10.15; p < 0.01) with better skin condition and lower bacterial growth in the Oil group (20% vs. 60%, p < 0.01). Coconut oil application reduced TEWL without increasing skin colonization in VLBW neonates. NCT01758068.

References

Oct 1, 1988·British Medical Bulletin·N Rutter
Jan 1, 1986·Biology of the Neonate·N J Evans, N Rutter
Sep 1, 1981·Archives of Disease in Childhood·N Rutter, D Hull
May 1, 1996·The Journal of Pediatrics·A J NopperA T Lane
Feb 24, 2000·Journal of Perinatology : Official Journal of the California Perinatal Association·R C PabstI H Gewolb
Aug 16, 2000·Pediatric Clinics of North America·G L Darmstadt, J G Dinulos
Jan 29, 2005·Journal of Tropical Pediatrics·Luke C MullanyJames M Tielsch

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Citations

Aug 8, 2020·Dermatologic Therapy·Mrinal Gupta, Shashank Bhargava
Jan 18, 2019·Pediatric Annals·Yasser Albahrani, Raegan Hunt
Feb 6, 2021·The Cochrane Database of Systematic Reviews·Maeve M KelleherRobert J Boyle

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