PMID: 9003951Dec 1, 1996Paper

Topical oxatomide: an alternative approach for the treatment of vulvar lichen sclerosus

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
M OrigoniA Ferrari

Abstract

The treatment of vulvar lichen sclerosus has greatly improved in recent years, with the introduction of new pharmacological approaches and reconsideration of the traditional ones. Oxatomide is a molecule with both antihistamine and inhibiting activities for the inflammatory response, which may have potential use against this disease. We enrolled 22 patients affected by vulvar lichen sclerosus in a double-blind, cross-over, controlled trial. They were administered a 5% oxatomide-based gel formulation and a placebo (petrolatum ointment) topically. At the beginning and the end of the investigation the severity and duration of symptoms, clinical appearance and tolerability were recorded. Statistical analysis of data was performed by Fisher's exact test and the Student-Newman-Keuls test. The results indicate that both regimens are significantly correlated with vulvar pruritus improvement and that 5% oxatomide gel has better anti-itching effects compared to the placebo. Other symptoms responded poorly to the treatment. The rate of complete-partial regression of pruritus was significantly higher (P < 0.05) in the oxatomide group than in controls, while no significant improvement was obtained neither with oxatomide or with placebo in t...Continue Reading

References

Jan 1, 1987·International Archives of Allergy and Applied Immunology·K TasakaN Nakaya
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Jul 1, 1994·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M SideriA Ferrari

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Citations

Apr 23, 2013·The British Journal of Dermatology·R C SimpsonR Murphy
Jul 24, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·G KirtschigF Wojnarowska
Feb 6, 2004·Dermatologic Therapy·Deana Funaro
Jan 8, 2013·Maturitas·Faustino R Pérez-LópezUNKNOWN EMAS, Spanish Menopause society
Nov 3, 2017·Journal of Lower Genital Tract Disease·Michal Sheinis, Amanda Selk
Dec 14, 2011·The Cochrane Database of Systematic Reviews·Ching-Chi ChiFenella Wojnarowska
Apr 28, 2004·American Journal of Clinical Dermatology·Yolanda R Smith, Hope K Haefner
Apr 1, 2021·Curēus·Nilanchali SinghPrafull Ghatage

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