Topical phenytoin suspension and normal saline in the treatment of leprosy trophic ulcers: a randomized, double-blind, comparative study

The Journal of Dermatological Treatment
A BhatiaB S N Reddy

Abstract

To evaluate and compare two strengths of topical phenytoin sodium suspension (2% and 4%) with normal saline in the healing of acute trophic ulcers in leprosy patients. A prospective, parallel, double-blind, randomized study was conducted in 45 leprosy inpatients with acute trophic ulcers. Patients were randomized to receive 2%, 4% or normal saline dressing on their ulcers once daily for 4 weeks. Efficacy parameters such as a reduction in the surface area of the ulcer, bacterial culture of the ulcer swab, appearance of healthy granulation tissue, cessation of ulcer discharge and overall gradation of clinical healing and safety were assessed at weekly intervals. The ulcer area reduction was greater in the 2% and 4% phenytoin groups compared with the normal saline group (p<0.001). Appearance of healthy granulation tissue and cessation of ulcer discharge was also observed earlier in the two phenytoin groups. At the end of 4 weeks, 11 ulcers each had healed completely in both the 2% and 4% phenytoin groups compared with none in the control group. There were no statistical differences between the 2% and 4% phenytoin groups. No side effects were reported by any patient. Topical phenytoin appears to be an effective, safe and cheap ther...Continue Reading

References

Oct 1, 1991·Diabetes Care·M G MuthukumarasamyG Manoharan
Jan 1, 1991·The British Journal of Surgery·S C LodhaM K Harsh
Mar 1, 1990·International Journal of Dermatology·H BogaertB Garcia
Jun 1, 1989·International Journal of Dermatology·S ModagheghA S Rezai
Mar 1, 1993·International Journal of Dermatology·A K PendseS Hada

❮ Previous
Next ❯

Citations

Aug 25, 2010·BMC Dermatology·Carlos Augusto Zanardini Pereira, Alice de Oliveira de A Alchorne
Feb 21, 2009·PloS One·Natasja H J van VeenW Cairns S Smith
Sep 18, 2014·Annals of Clinical Microbiology and Antimicrobials·José M RamosMiguel Górgolas
Aug 21, 2010·International Wound Journal·Hewa Fonsekage Sanjeewani FonsekaManel Dissanayake
Feb 23, 2011·International Journal of Surgery·Emad HokkamMamdouh El-Mezaien
Mar 29, 2014·Revista da Escola de Enfermagem da U S P·Flávia FirminoLúcia Helena Garcia Penna
Nov 17, 2009·Foot & Ankle International·Dimitrios N LyrasEfstratios Patsouris
Feb 23, 2017·The Cochrane Database of Systematic Reviews·Xiang Yong HaoYan Fei Shen
Jul 23, 2008·The Cochrane Database of Systematic Reviews·Liv Merete ReinarDiana Lockwood
Aug 20, 2019·The Cochrane Database of Systematic Reviews·Liv Merete ReinarKjetil G Brurberg
Mar 9, 2021·Journal of Clinical Orthopaedics and Trauma·C Shyam KumarCh R S Ayyappa Naidu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Sofia SpaiaGeorgios Vayonas
The Cochrane Database of Systematic Reviews
Natasja H J van VeenJan H Richardus
The Cochrane Database of Systematic Reviews
Liv Merete ReinarDiana N J Lockwood
International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association
Ravi H NK R John
© 2021 Meta ULC. All rights reserved