Topical phenytoin versus EUSOL in the treatment of non-malignant chronic leg ulcers

East African Medical Journal
P M R Carneiro, E T M Nyawawa

Abstract

To compare topical diphenylhydantoin (phenytoin) with Edinburgh University solution of lime (EUSOL) in terms of rate of ulcer healing, analgesic and antibacterial properties in non-malignant chronic leg ulcers. A prospective randomized controlled study. Muhimbili National Hospital surgical wards from August 2000 to September 2001. One hundred and two patients with non-malignant chronic leg ulcers of various aetiologies, 50 in the study (phenytoin)group and 52 in the control(EUSOL) group. Study group studied by sprinkling phenytoin powder and the control group with EUSOL, in both groups the ulcers were addressed daily and followed up for 28 days or until they epithelialised or were ready for skin grafting. The data collected included demographic characteristics of patients, aetiology of the ulcers, pus discharge, severity of pain due to the ulcers, bacterial cultures from ulcer swabs, rate of reduction in mean ulcer surface area and outcome of treatment. The study enrolled 67 male and 35 female patients over a 14 month period (August to September 2001). Fifty patients formed the study group and 52 formed the controls. The age range was 12-56 years; the majority being in the 27-31 year age group. Major causes of chronic leg ulcer...Continue Reading

Citations

Feb 5, 2005·The Veterinary Clinics of North America. Equine Practice·Andrew J DartChristine L Smith

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