Topical provocation in fixed drug eruption due to metamizol and naproxen

Clinical and Experimental Dermatology
E Ozkaya-Bayazit

Abstract

The aim of this study was to investigate the usefulness of topical provocation in the diagnosis of metamizol- and naproxen-induced fixed drug eruption (FDE). Five patients with metamizol- and four patients with naproxen-induced FDE established by oral provocation were tested with the causative drugs at concentrations of 10%, 20%, and 50% in white petrolatum both on previously involved and uninvolved skin using the occlusive patch test technique. Additionally, four patients with metamizol- and five patients with naproxen-induced FDE, and 20 healthy controls were tested openly with drug preparations in dimethyl sulfoxide (DMSO). Tape-stripping occlusive patch testing in petrolatum remained negative in all. Open testing with drug preparations in DMSO revealed positive results in all four patients tested with metamizol mainly at concentrations of 20%, and in three of five patients tested with naproxen exclusively at concentrations of 50%. No positive reaction was seen on previously uninvolved skin and in healthy controls with any drug concentration and pure DMSO. In conclusion, repeated open testing with concentrations of the drugs up to 50% in DMSO seems to be a reliable test method in metamizol-induced FDE whereas oral provocatio...Continue Reading

References

Apr 1, 1987·The British Journal of Dermatology·K AlankoS Reitamo
Jan 1, 1987·Dermatologica·L Habbema, D P Bruynzeel
Oct 9, 1999·Contact Dermatitis·E Ozkaya-BayazitG Ozarmagan
Feb 24, 2001·Pediatric Dermatology·M Díaz JaraM I Martínez Molero
Jun 26, 2001·The British Journal of Dermatology·M A GonzaloG González
Sep 13, 2001·Contact Dermatitis·M A Gonzalo-GarijoI Rodríguez-Nevado
Nov 13, 2001·The British Journal of Dermatology·J A Savin
May 2, 2002·International Journal of Dermatology·Hong LiRobert A Schwartz
Sep 6, 1965·JAMA : the Journal of the American Medical Association·A M KLIGMAN
Nov 26, 2003·Journal of the American Academy of Dermatology·Esen Ozkaya-Bayazit

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Citations

Apr 25, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·I Leonard BernsteinUNKNOWN American College of Allergy, Asthma and Immunology
Oct 17, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·UNKNOWN American Academy of Allergy, Asthma and Immunology, UNKNOWN American College of Allergy, Asthma and Immunology
Apr 3, 2008·Dermatology : International Journal for Clinical and Investigative Dermatology·Kilian EyerichRüdiger Hein
Dec 14, 2007·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Esen Ozkaya
Jun 28, 2011·Contact Dermatitis·Pedro AndradeMargarida Gonçalo
Mar 4, 2011·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Alessandra HandisuryaStefan Wöhrl
Nov 10, 2015·Annales de dermatologie et de vénéréologie·L Valeyrie-AllanoreUNKNOWN sous l’égide du groupe toxidermie de la Société française de dermatologie (FISARD)
Mar 2, 2011·Human & Experimental Toxicology·Hikmet AkyaziIsmail Hamdi Kara

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